8CV5
| Peptide 4.2B in complex with BRD3.2 | 分子名称: | ACETYL GROUP, AMINO GROUP, Bromodomain-containing protein 3, ... | 著者 | Franck, C, Mackay, J.P. | 登録日 | 2022-05-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
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8CV7
| Peptide 2.2E in complex with BRD2-BD2 | 分子名称: | ACETYL GROUP, AMINO GROUP, Isoform 3 of Bromodomain-containing protein 2, ... | 著者 | Franck, C, Mackay, J.P. | 登録日 | 2022-05-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
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8CV4
| Peptide 4.2C in complex with BRD4.2 | 分子名称: | ACETYL GROUP, AMINO GROUP, BRD4 protein, ... | 著者 | Franck, C, Mackay, J.P. | 登録日 | 2022-05-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
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8CV6
| Peptide 4.2B in complex with BRD4.2 | 分子名称: | ACETYL GROUP, AMINO GROUP, BRD4 protein, ... | 著者 | Franck, C, Mackay, J.P. | 登録日 | 2022-05-18 | 公開日 | 2023-05-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
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3P5O
| Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, Bromodomain-containing protein 4 | 著者 | Chung, C. | 登録日 | 2010-10-09 | 公開日 | 2010-11-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Suppression of inflammation by a synthetic histone mimic Nature, 468, 2010
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3P1F
| Crystal structure of the bromodomain of human CREBBP in complex with a hydroquinazolin ligand | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-3,4-dihydroquinazolin-2(1H)-one, CREB-binding protein, ... | 著者 | Filippakopoulos, P, Picaud, S, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-30 | 公開日 | 2010-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Crystal structure of the bromodomain of human CREBBP in complex with a hydroquinazolin ligand To be Published
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8OU2
| Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor | 分子名称: | 1,2-ETHANEDIOL, 7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... | 著者 | Balikci, E, Ni, X, Bountra, C, von Delft, F, Huber, K. | 登録日 | 2023-04-21 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor To Be Published
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8EAD
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3P1D
| Crystal structure of the bromodomain of human CREBBP in complex with N-Methyl-2-pyrrolidone (NMP) | 分子名称: | 1-methylpyrrolidin-2-one, CREB-binding protein, POTASSIUM ION, ... | 著者 | Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-30 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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3P1C
| Crystal structure of the bromodomain of human CREBBP in complex with acetylated lysine | 分子名称: | CREB-binding protein, N(6)-ACETYLLYSINE, POTASSIUM ION, ... | 著者 | Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-30 | 公開日 | 2010-11-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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3MQM
| Crystal Structure of the Bromodomain of human ASH1L | 分子名称: | Probable histone-lysine N-methyltransferase ASH1L | 著者 | Filippakopoulos, P, Picaud, S, Keates, T, Felletar, I, Vollmar, M, Chaikuad, A, Krojer, T, Canning, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-04-28 | 公開日 | 2010-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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3MB3
| Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) | 分子名称: | 1-methylpyrrolidin-2-one, PH-interacting protein | 著者 | Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-03-25 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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8G6T
| Bromodomain of CBP liganded with inhibitor iCBP2 | 分子名称: | (6S)-1-(3,4-dibromophenyl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, CREB-binding protein, NICKEL (II) ION | 著者 | Schonbrunn, E, Bikowitz, M. | 登録日 | 2023-02-15 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
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8GA2
| Bromodomain of CBP liganded with inhibitor iCBP5 | 分子名称: | (6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein | 著者 | Schonbrunn, E, Bikowitz, M. | 登録日 | 2023-02-22 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
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3MXF
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1 | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-07 | 公開日 | 2010-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Selective inhibition of BET bromodomains. Nature, 468, 2010
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8PX2
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8PXM
| N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(pentane-1,5-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one) | 分子名称: | (1R)-7-[5-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]pentoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Chung, C.W. | 登録日 | 2023-07-23 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.378 Å) | 主引用文献 | Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8PX8
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8PXA
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8E17
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P,6M)-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-4-[5-(methanesulfonyl)-2-methoxyphenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-09 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8E3W
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-17 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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3P1E
| Crystal structure of the bromodomain of human CREBBP in complex with dimethyl sulfoxide (DMSO) | 分子名称: | CREB-binding protein, DIMETHYL SULFOXIDE, POTASSIUM ION, ... | 著者 | Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-30 | 公開日 | 2010-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the bromodomain of human CREBBP in complex with dimethyl sulfoxide (DMSO) To be Published
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8DYR
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P,6P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-04 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8DNQ
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8SB6
| Structure of human BRD2-BD1 bound to a histone H4 acetyl-methyllysine peptide | 分子名称: | Bromodomain containing 2, Histone H4 | 著者 | Connor, L.J, Ekundayo, B.E, Lu-Culligan, W.J, Simon, M.D, Bleichert, F. | 登録日 | 2023-04-02 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Acetyl-methyllysine marks chromatin at active transcription start sites. Nature, 622, 2023
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