8DNQ

BRD2-BD1 in complex with cyclic peptide 2.2B

Summary for 8DNQ

Entry DOI	10.2210/pdb8dnq/pdb
Descriptor	Bromodomain-containing protein 2, Cyclic peptide 2.2B, GLYCEROL, ... (4 entities in total)
Functional Keywords	cyclic peptide, bromodomain, brd2, bet, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	36228.06
Authors	Patel, K.,Franck, C.,Mackay, J.P. (deposition date: 2022-07-11, release date: 2023-07-19, Last modification date: 2023-12-06)
Primary citation	Franck, C.,Patel, K.,Walport, L.J.,Christie, M.,Norman, A.,Passioura, T.,Suga, H.,Payne, R.J.,Mackay, J.P. Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31:912-923.e4, 2023 Cited by PubMed: 37269828 DOI: 10.1016/j.str.2023.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation