8CV6

Peptide 4.2B in complex with BRD4.2

Summary for 8CV6

Entry DOI	10.2210/pdb8cv6/pdb
Descriptor	BRD4 protein, Peptide 4.2E, ACETYL GROUP, ... (5 entities in total)
Functional Keywords	cyclic peptide inhibitor bromodomain, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	16351.91
Authors	Franck, C.,Mackay, J.P. (deposition date: 2022-05-18, release date: 2023-05-24, Last modification date: 2023-12-06)
Primary citation	Franck, C.,Patel, K.,Walport, L.J.,Christie, M.,Norman, A.,Passioura, T.,Suga, H.,Payne, R.J.,Mackay, J.P. Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31:912-923.e4, 2023 Cited by PubMed: 37269828 DOI: 10.1016/j.str.2023.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation