8PX2

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1,3-dimethyl-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

Summary for 8PX2

Entry DOI	10.2210/pdb8px2/pdb
Descriptor	Bromodomain-containing protein 2, 1,3-dimethyl-5-[1-(oxan-4-ylmethyl)benzimidazol-2-yl]pyridin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	bromodomain inhibitor, complex, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	13965.11
Authors	Chung, C.W. (deposition date: 2023-07-22, release date: 2023-10-18, Last modification date: 2023-12-27)
Primary citation	Bradley, E.,Fusani, L.,Chung, C.W.,Craggs, P.D.,Demont, E.H.,Humphreys, P.G.,Mitchell, D.J.,Phillipou, A.,Rioja, I.,Shah, R.R.,Wellaway, C.R.,Prinjha, R.K.,Palmer, D.S.,Kerr, W.J.,Reid, M.,Wall, I.D.,Cookson, R. Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66:15728-15749, 2023 Cited by PubMed: 37967462 DOI: 10.1021/acs.jmedchem.3c00906 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.622 Å)

Structure validation