8OU2

Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor

Summary for 8OU2

• Entry DOI: 10.2210/pdb8ou2/pdb
• Descriptor: Nucleosome-remodeling factor subunit BPTF, 7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one, GLYCEROL, ... (6 entities in total)
• Functional Keywords: nucleosome-remodeling factor subunit bptf, inhibitor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 30558.71

Authors

Balikci, E.,Ni, X.,Bountra, C.,von Delft, F.,Huber, K. (deposition date: 2023-04-21, release date: 2024-05-01)

• Primary citation: Balikci, E.,Ni, X.,Bountra, C.,von Delft, F.,Huber, K.; Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)