8OU2
Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nucleosome-remodeling factor subunit BPTF | polymer | 123 | 14455.4 | 2 | UniProt (Q12830) Pfam (PF00439) | Homo sapiens (human) | Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen |
| 2 | C, H (A, B) | 7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one | non-polymer | 537.6 | 2 | Chemie (W2W) | |||
| 3 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | F, G, I, J, K (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | L (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 354 | Chemie (HOH) |
Sequence modifications
A, B: 2917 - 3037 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Ser 2915 | - | expression tag |
| Met 2916 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28910.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1647.9 | |
| All* | Total formula weight | 30558.7 |
