8DYR

BRD4-D1 in complex with BET inhibitor

Summary for 8DYR

Entry DOI	10.2210/pdb8dyr/pdb
Descriptor	Bromodomain-containing protein 4, (4P,6P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, bet inhibitor, brd4, pet radiotracer, solid tumor imaging, gene regulation
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15658.00
Authors	Gorman, M.A.,Fitzgerald, C.G.D.,White, J.M.,Parker, M.W. (deposition date: 2022-08-04, release date: 2023-03-29, Last modification date: 2023-10-25)
Primary citation	Dickmann, C.G.F.,McDonald, A.F.,Huynh, N.,Rigopoulos, A.,Liu, Z.,Guo, N.,Osellame, L.D.,Gorman, M.A.,Parker, M.W.,Gan, H.K.,Scott, A.M.,Ackermann, U.,Burvenich, I.J.G.,White, J.M. Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59:3126-3129, 2023 Cited by PubMed: 36809538 DOI: 10.1039/d2cc04813b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation