8CV7

Peptide 2.2E in complex with BRD2-BD2

Summary for 8CV7

Entry DOI	10.2210/pdb8cv7/pdb
Descriptor	Isoform 3 of Bromodomain-containing protein 2, Peptide 2.2E, ACETYL GROUP, ... (5 entities in total)
Functional Keywords	bromodomain cyclic peptides acetyl-lysine, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	30058.58
Authors	Franck, C.,Mackay, J.P. (deposition date: 2022-05-18, release date: 2023-05-24, Last modification date: 2023-12-06)
Primary citation	Franck, C.,Patel, K.,Walport, L.J.,Christie, M.,Norman, A.,Passioura, T.,Suga, H.,Payne, R.J.,Mackay, J.P. Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31:912-923.e4, 2023 Cited by PubMed: 37269828 DOI: 10.1016/j.str.2023.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation