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PDB: 428 件
7BBF
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BU of 7bbf by Molmil
Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2
分子名称: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Kiss, L, Neuhaus, D, James, L.C.
登録日2020-12-17
公開日2021-01-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
8OIF
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BU of 8oif by Molmil
Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N.
登録日2023-03-22
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.
Nat Commun, 14, 2023
8JWJ
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BU of 8jwj by Molmil
PHD Finger Protein 7 (PHF7) in complex with UBE2D2
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, PHD finger protein 7, ...
著者Lee, H.S, Bang, I, Choi, H.-J.
登録日2023-06-29
公開日2023-12-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Molecular basis for PHF7-mediated ubiquitination of histone H3.
Genes Dev., 37, 2023
8JWU
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BU of 8jwu by Molmil
PHD Finger Protein 7 (PHF7) fused to UBE2D2 via a (GSGG)3 linker
分子名称: PHD finger protein 7,Ubiquitin-conjugating enzyme E2 D2, ZINC ION
著者Lee, H.S, Bang, I, Choi, H.-J.
登録日2023-06-29
公開日2023-12-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.58 Å)
主引用文献Molecular basis for PHF7-mediated ubiquitination of histone H3.
Genes Dev., 37, 2023
7AI1
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BU of 7ai1 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AHZ
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BU of 7ahz by Molmil
Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
8ODR
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BU of 8odr by Molmil
Mimetic of UBC9-SUMO1
分子名称: SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1
著者Coste, F, Goffinont, S, Suskiewicz, M.J.
登録日2023-03-09
公開日2023-06-07
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic.
J.Biol.Chem., 299, 2023
8IVQ
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BU of 8ivq by Molmil
Cryo-EM structure of mouse BIRC6, Global map
分子名称: Isoform 2 of Baculoviral IAP repeat-containing protein 6
著者Liu, S, Jiang, T, Bu, F, Zhao, J, Wang, G, Li, N, Gao, N, Qiu, X.
登録日2023-03-28
公開日2024-01-24
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy.
Nat Commun, 15, 2024
8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
登録日2023-06-27
公開日2023-09-27
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
登録日2023-06-27
公開日2023-09-27
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
2EKE
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BU of 2eke by Molmil
Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent Ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway
分子名称: SUMO-conjugating enzyme UBC9, Ubiquitin-like protein SMT3
著者Duda, D.M, Schulman, B.A.
登録日2007-03-23
公開日2007-05-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of a SUMO-binding-motif Mimic Bound to Smt3p-Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein-E2 Complex as a Platform for Selective Interactions within a SUMO Pathway
J.Mol.Biol., 369, 2007
2C2V
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BU of 2c2v by Molmil
Crystal structure of the CHIP-UBC13-UEV1a complex
分子名称: STIP1 homology and U box-containing protein 1, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1
著者Zhang, M, Roe, S.M, Pearl, L.H.
登録日2005-09-30
公開日2005-11-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Mol. Cell, 20, 2005
2BF8
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BU of 2bf8 by Molmil
Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K
分子名称: UBIQUITIN-CONJUGATING ENZYME E2-25 KDA, UBIQUITIN-LIKE PROTEIN SMT3C
著者Pichler, A, Knipscheer, P, Oberhofer, E, Van Dijk, W.J, Korner, R, Velgaard Olsen, J, Jentsch, S, Melchior, F, Sixma, T.K.
登録日2004-12-06
公開日2005-02-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Sumo Imodification of the Ubiquitin Conjugating Enzyme E2-25K
Nat.Struct.Mol.Biol., 12, 2005
2FUH
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BU of 2fuh by Molmil
Solution Structure of the UbcH5c/Ub Non-covalent Complex
分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 D3
著者Brzovic, P.S, Lissounov, A, Hoyt, D.W, Klevit, R.E.
登録日2006-01-26
公開日2006-03-28
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination.
Mol.Cell, 21, 2006
1YLA
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BU of 1yla by Molmil
Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2)
分子名称: Ubiquitin-conjugating enzyme E2-25 kDa
著者Choe, J, Avvakumov, G.V, Newman, E.M, Mackenzie, F, Kozieradzki, I, Bochkarev, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-paganon, S, Structural Genomics Consortium (SGC)
登録日2005-01-19
公開日2005-02-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
1ZGU
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BU of 1zgu by Molmil
Solution structure of the human Mms2-Ubiquitin complex
分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 variant 2
著者Lewis, M.J, Saltibus, L.F, Hau, D.D, Xiao, W, Spyracopoulos, L.
登録日2005-04-22
公開日2006-04-04
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural Basis for Non-Covalent Interaction Between Ubiquitin and the Ubiquitin Conjugating Enzyme Variant Human MMS2.
J.Biomol.Nmr, 34, 2006
1Y8X
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BU of 1y8x by Molmil
Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1
分子名称: Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M
著者Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A.
登録日2004-12-13
公開日2005-02-08
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
1Z5S
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BU of 1z5s by Molmil
Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2
分子名称: Ran GTPase-activating protein 1, Ran-binding protein 2, Ubiquitin-conjugating enzyme E2 I, ...
著者Reverter, D, Lima, C.D.
登録日2005-03-19
公開日2005-06-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
Nature, 435, 2005
8SEB
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BU of 8seb by Molmil
Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SV8
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BU of 8sv8 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-05-15
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SE9
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BU of 8se9 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2)
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SEA
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BU of 8sea by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1)
分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
著者Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
登録日2023-04-08
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8T0S
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BU of 8t0s by Molmil
Crystal structure of UBE2G2 adduct with phenethyl isothiocyanate (PEITC) at the Cys48 position
分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase AMFR, Ubiquitin-conjugating enzyme E2 G2
著者Wang, C, Shaw, G.X, Shi, G, Ji, X.
登録日2023-06-01
公開日2024-06-05
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of UBE2G2 adduct with phenethyl isothiocyanate (PEITC) at the Cys48 position
To be published
9B5O
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BU of 9b5o by Molmil
Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 10 map and model from consensus
分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Kochanczyk, T, Lima, C.D.
登録日2024-03-22
公開日2024-06-05
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structural basis for transthiolation intermediates in the ubiquitin pathway
Nature, 2024
9B5N
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BU of 9b5n by Molmil
Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 1 map and model from consensus
分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Kochanczyk, T, Lima, C.D.
登録日2024-03-22
公開日2024-06-05
最終更新日2024-08-14
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structural basis for transthiolation intermediates in the ubiquitin pathway
Nature, 2024

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件を2024-08-14に公開中

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