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PDB: 730 件
1I57
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CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
分子名称: CHLORIDE ION, MAGNESIUM ION, PHOSPHO-TYROSINE PHOSPHATASE 1B
著者Scapin, G, Patel, S, Patel, V, Kennedy, B, Asante-Appiah, E.
登録日2001-02-26
公開日2001-08-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
8EYC
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Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
分子名称: Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-26
公開日2023-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
1LQF
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Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor
分子名称: N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE, protein-tyrosine phosphatase, non-receptor type 1
著者Asante-Appiah, E, Patel, S, Dufresne, C, Scapin, G.
登録日2002-05-10
公開日2002-07-24
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Biochemistry, 41, 2002
1JF7
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HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836
分子名称: 5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID, PROTEIN-TYROSINE PHOSPHATASE 1B
著者Larsen, S.D, Barf, T, Liljebris, C, May, P.D, Ogg, D, O'Sullivan, T.J, Palazuk, B.J, Schostarez, H.J, Stevens, F.C, Bleasdale, J.E.
登録日2001-06-20
公開日2002-02-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
J.Med.Chem., 45, 2002
1JLN
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Crystal structure of the catalytic domain of protein tyrosine phosphatase PTP-SL/BR7
分子名称: Protein Tyrosine Phosphatase, receptor type, R
著者Szedlacsek, S.E, Aricescu, A.R, Fulga, T.A, Renault, L, Scheidig, A.J.
登録日2001-07-16
公開日2001-08-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
J.Mol.Biol., 311, 2001
1LYV
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High-resolution structure of the catalytically inactive yersinia tyrosine phosphatase C403A mutant in complex with phosphate.
分子名称: CHLORIDE ION, PHOSPHATE ION, PROTEIN-TYROSINE PHOSPHATASE YOPH
著者Evdokimov, A.G, Waugh, D.S, Routzahn, K, Tropea, J, Cherry, S.
登録日2002-06-08
公開日2002-07-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.363 Å)
主引用文献High-resolution structure of the catalytically inactive yersinia tyrosine phosphatase C403A mutant in complex with phosphate.
To be Published
1WCH
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Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
分子名称: PHOSPHATE ION, PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13
著者Villa, F, Deak, M, Bloomberg, G.B, Alessi, D.R, Van Aalten, D.M.F.
登録日2004-11-16
公開日2004-12-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket
J.Biol.Chem., 280, 2005
1XBO
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PTP1B complexed with Isoxazole Carboxylic Acid
分子名称: 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID, Protein-tyrosine phosphatase, non-receptor type 1
著者Zhao, H, Liu, G, Xin, Z, Serby, M, Pei, Z, Szczepankiewicz, B.G, Hajduk, P.J, Abad-Zapatero, C, Hutchins, C.W, Lubben, T.H, Ballaron, S.J, Hassach, D.L, Kaszubska, W, Rondinone, C.M, Trevillyan, J.M, Jirousek, M.R.
登録日2004-08-31
公開日2004-10-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
1XXP
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Yersinia YopH (residues 163-468) C403S binds phosphotyrosyl peptide at two sites
分子名称: Hexapeptide ASP-ALA-ASP-GLU-PTR-CLE, Protein-tyrosine phosphatase yopH
著者Ivanov, M.I, Stuckey, J.A, Schubert, H.L, Saper, M.A, Bliska, J.B.
登録日2004-11-07
公開日2005-03-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence
Mol.Microbiol., 55, 2005
1YTN
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HYDROLASE
分子名称: NITRATE ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE
著者Yuvaniyama, C, Fauman, E.B, Saper, M.A.
登録日1996-05-01
公開日1996-11-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
J.Biol.Chem., 271, 1996
1YFO
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RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA, DOMAIN 1 FROM MOUSE
分子名称: RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA
著者Bilwes, A.M, Noel, J.P.
登録日1996-12-11
公開日1997-04-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization.
Nature, 382, 1996
1YPT
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CRYSTAL STRUCTURE OF YERSINIA PROTEIN TYROSINE PHOSPHATASE AT 2.5 ANGSTROMS AND THE COMPLEX WITH TUNGSTATE
分子名称: PROTEIN-TYROSINE PHOSPHATASE YERSINIA (CATALYTIC DOMAIN)
著者Stuckey, J.A, Schubert, H.L, Fauman, E.B, Zhang, Z.-Y, Dixon, J.E, Saper, M.A.
登録日1994-09-16
公開日1994-12-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate.
Nature, 370, 1994
1YTS
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A LIGAND-INDUCED CONFORMATIONAL CHANGE IN THE YERSINIA PROTEIN TYROSINE PHOSPHATASE
分子名称: SULFATE ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE
著者Schubert, H.L, Stuckey, J.A, Fauman, E.B, Dixon, J.E, Saper, M.A.
登録日1995-04-07
公開日1995-07-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Protein Sci., 4, 1995
1ZC0
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Crystal structure of human hematopoietic tyrosine phosphatase (HePTP) catalytic domain
分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase, non-receptor type 7
著者Page, R, Mustelin, T.
登録日2005-04-09
公開日2005-12-06
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
J.Mol.Biol., 354, 2005
1YGU
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Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide
分子名称: Leukocyte common antigen, Polyoma Middle T antigen
著者Nam, H, Poy, F, Saito, H, Frederick, C.A.
登録日2005-01-05
公開日2005-02-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201, 2005
1YTW
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YERSINIA PTPASE COMPLEXED WITH TUNGSTATE
分子名称: SULFATE ION, TUNGSTATE(VI)ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE
著者Fauman, E.B, Schubert, H.L, Saper, M.A.
登録日1996-05-01
公開日1996-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
J.Biol.Chem., 271, 1996
2A8B
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Crystal Structure of the Catalytic Domain of Human Tyrosine Phosphatase Receptor, Type R
分子名称: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase R
著者Ugochukwu, E, Eswaran, J, Barr, A, Longman, E, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
登録日2005-07-07
公開日2005-07-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem.J., 395, 2006
1XXV
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Yersinia YopH (residues 163-468) binds phosphonodifluoromethyl-Phe containing hexapeptide at two sites
分子名称: Epidermal growth factor receptor derived peptide, Protein-tyrosine phosphatase yopH
著者Ivanov, M.I, Stuckey, J.A, Schubert, H.L, Saper, M.A, Bliska, J.B.
登録日2004-11-08
公開日2005-03-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence
Mol.Microbiol., 55, 2005
2A3K
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Crystal Structure of the Human Protein Tyrosine Phosphatase, PTPN7 (HePTP, Hematopoietic Protein Tyrosine Phosphatase)
分子名称: PHOSPHATE ION, protein tyrosine phosphatase, non-receptor type 7, ...
著者Barr, A, Turnbull, A.P, Das, S, Eswaran, J, Debreczeni, J.E, Longmann, E, Smee, C, Burgess, N, Gileadi, O, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
登録日2005-06-24
公開日2005-07-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
1YGR
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Crystal structure of the tandem phosphatase domain of RPTP CD45
分子名称: CD45 Protein Tyrosine Phosphatase, T-cell Receptor CD3 zeta ITAM-1
著者Nam, H.J, Poy, F, Saito, H, Frederick, C.A.
登録日2005-01-05
公開日2005-02-22
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201, 2005
1C87
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
分子名称: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
登録日2000-04-16
公開日2000-05-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C85
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
分子名称: 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
登録日2000-04-16
公開日2000-05-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C88
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
登録日2000-04-16
公開日2000-05-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C83
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
分子名称: 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
登録日2000-04-14
公開日2000-05-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C84
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
分子名称: 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
登録日2000-04-14
公開日2000-05-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000

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