1C84

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID

Summary for 1C84

Related1ECV 1C83 1C85 1C86 1C87 1C88
DescriptorPROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywordshydrolase, phosphorylation, ligand, inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side  P18031
Total number of polymer chains1
Total molecular weight34979.78
Authors
Andersen, H.S.,Iversen, L.F.,Branner, S.,Rasmussen, H.B.,Moller, N.P. (deposition date: 2000-04-14, release date: 2000-05-03, Last modification date: 2018-03-07)
Primary citation
Andersen, H.S.,Iversen, L.F.,Jeppesen, C.B.,Branner, S.,Norris, K.,Rasmussen, H.B.,Moller, K.B.,Moller, N.P.
2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275:7101-7108, 2000
PubMed: 10702277 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.275.10.7101
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers6 1.0% 8.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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170172
PDB entries from 2020-10-21