2A8B

Crystal Structure of the Catalytic Domain of Human Tyrosine Phosphatase Receptor, Type R

Replaces:  1ZEP

Summary for 2A8B

• Entry DOI: 10.2210/pdb2a8b/pdb
• Related: 1JLN
• Descriptor: Receptor-type tyrosine-protein phosphatase R, CHLORIDE ION (3 entities in total)
• Functional Keywords: protein tyrosine phosphatase, receptor, human, structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cytoplasm, perinuclear region. Isoform Gamma: Cytoplasm, perinuclear region: Q15256
• Total number of polymer chains: 1
• Total formula weight: 32319.49

Authors

Ugochukwu, E.,Eswaran, J.,Barr, A.,Longman, E.,Arrowsmith, C.,Edwards, A.,Sundstrom, M.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2005-07-07, release date: 2005-07-19, Last modification date: 2023-08-23)

• Primary citation: Eswaran, J.,von Kries, J.P.,Marsden, B.,Longman, E.,Debreczeni, J.E.,Ugochukwu, E.,Turnbull, A.,Lee, W.H.,Knapp, S.,Barr, A.J.; Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.; Biochem.J., 395:483-491, 2006; PubMed: 16441242; DOI: 10.1042/BJ20051931

Experimental method

X-RAY DIFFRACTION (2.3 Å)