1JF7

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836

Summary for 1JF7

Entry DOI	10.2210/pdb1jf7/pdb
Related	1G7F 1G7G
Descriptor	PROTEIN-TYROSINE PHOSPHATASE 1B, 5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID (3 entities in total)
Functional Keywords	hydrolase (phosphorylation), tyrosine phosphatase, inhibitor, complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	2
Total formula weight	70046.85
Authors	Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E. (deposition date: 2001-06-20, release date: 2002-02-13, Last modification date: 2023-08-16)
Primary citation	Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E. Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B. J.Med.Chem., 45:598-622, 2002 Cited by PubMed: 11806712 DOI: 10.1021/jm010393s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation