4LZ7
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4MH5
| Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate | 分子名称: | CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... | 著者 | Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. | 登録日 | 2013-08-29 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J.Struct.Biol., 176, 2011
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8E94
| PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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4E0X
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8E93
| D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E97
| PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.19 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E99
| Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E92
| D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E96
| Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ... | 著者 | Kang, H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8E98
| D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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8BN2
| Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with D-Serine | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Heroven, C, Malinauskas, T, Aricescu, A.R. | 登録日 | 2022-11-11 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | GluD1 binds GABA and controls inhibitory plasticity. Science, 382, 2023
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8BN5
| Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with GABA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Heroven, C, Malinauskas, T, Aricescu, A.R. | 登録日 | 2022-11-12 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | GluD1 binds GABA and controls inhibitory plasticity. Science, 382, 2023
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8BLJ
| Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1), apo state | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Heroven, C, Malinauskas, T, Aricescu, A.R. | 登録日 | 2022-11-09 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | GluD1 binds GABA and controls inhibitory plasticity. Science, 382, 2023
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8BSU
| Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate and the positive allosteric modulator BPAM344 at 2.9A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2022-11-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. Febs J., 291, 2024
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8BST
| Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate at 2.7A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ACETATE ION, CHLORIDE ION, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2022-11-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. Febs J., 291, 2024
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4F29
| Quisqualate bound to the ligand binding domain of GluA3i | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2012-05-07 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F1Y
| CNQX bound to the ligand binding domain of GluA3 | 分子名称: | 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2012-05-07 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F2Q
| Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2012-05-08 | 公開日 | 2012-05-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4NF4
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | 分子名称: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | 著者 | Annie, J, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4DLD
| Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution | 分子名称: | (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2012-02-06 | 公開日 | 2012-10-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors Chemmedchem, 7, 2012
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8C2H
| Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1P
| Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1S
| Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C2I
| Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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8C1R
| Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... | 著者 | Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. | 登録日 | 2022-12-21 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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