8BSU

Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate and the positive allosteric modulator BPAM344 at 2.9A resolution

Summary for 8BSU

• Entry DOI: 10.2210/pdb8bsu/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 3, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ZINC ION, ... (9 entities in total)
• Functional Keywords: ionotropic glutamate receptor, gluk3 ligand-binding domain, membrane protein, gluk3-h523a-lbd, positive allosteric modulator, bpam344
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 8
• Total formula weight: 240078.07

Authors

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2022-11-26, release date: 2023-12-13)

• Primary citation: Bay, Y.,Venskutonyte, R.,Frantsen, S.M.,Thorsen, T.S.,Musgaard, M.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Biggin, P.C.,Kristensen, A.S.,Boesen, T.,Pickering, D.S.,Gajhede, M.,Kastrup, J.S.; Positive allosteric modulation of homomeric kainate receptors GluK1-3; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)