4DLD

Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution

Summary for 4DLD

• Entry DOI: 10.2210/pdb4dld/pdb
• Related: 3TZA
• Descriptor: Glutamate receptor, ionotropic kainate 1, (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: ionotropic glutamate receptor, glutamate, membrane, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59073.90

Authors

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2012-02-06, release date: 2012-10-10, Last modification date: 2023-11-08)

• Primary citation: Venskutonyte, R.,Frydenvang, K.,Valades, E.A.,Szymanska, E.,Johansen, T.N.,Kastrup, J.S.,Pickering, D.S.; Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors; Chemmedchem, 7:1793-1798, 2012; PubMed: 22407805; DOI: 10.1002/cmdc.201100599

Experimental method

X-RAY DIFFRACTION (2 Å)