4DLD
Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor, ionotropic kainate 1 | polymer | 257 | 29108.5 | 2 | UniProt (P22756) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (rat) | Glutamate receptor 5, GluR-5, GluR5 |
| 2 | C, E (A, B) | (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid | non-polymer | 316.7 | 2 | Chemie (TZG) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 116 (UniProt: P22756)
A, B: 119 - 257 (UniProt: P22756)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Gly 34 | Ala 462 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Gly 117 | - | linker |
| Thr 118 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58216.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 857.0 | |
| All* | Total formula weight | 59073.9 |
