8V52
 
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1TFG
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7RCO
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7L0J
 | | Structure of AMH bound to AMHR2-ECD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... | | 著者 | Hart, K.N, Thompson, T.B. | | 登録日 | 2020-12-11 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6OMO
 | | Human BMP6 homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 6, ... | | 著者 | Juo, Z.S, Seeherman, H. | | 登録日 | 2019-04-19 | | 公開日 | 2019-05-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
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6OMN
 | | Glycosylated BMP2 homodimer | | 分子名称: | Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Juo, Z.S, Seeherman, H. | | 登録日 | 2019-04-19 | | 公開日 | 2019-05-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
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4KV5
 | | scFv GC1009 in complex with TGF-beta1. | | 分子名称: | Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein | | 著者 | Wei, R, Moulin, A.G, Mathieu, M. | | 登録日 | 2013-05-22 | | 公開日 | 2014-09-24 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
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8E3G
 | | BMP2/GDF5 heterodimer | | 分子名称: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | | 著者 | Gipson, G.R, Nolan, K.T, Thompson, T.B. | | 登録日 | 2022-08-17 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21, 2023
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1WAQ
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4KXZ
 | | crystal structure of tgfb2 in complex with GC2008. | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ... | | 著者 | Mathieu, M, Moulin, A.G, Wei, R. | | 登録日 | 2013-05-28 | | 公開日 | 2014-09-24 | | 最終更新日 | 2014-12-03 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
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1TGJ
 | | HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3 | | 著者 | Mittl, P.R.E, Priestle, J.P, Gruetter, M.G. | | 登録日 | 1996-07-09 | | 公開日 | 1997-01-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
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6XM2
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1BMP
 | | BONE MORPHOGENETIC PROTEIN-7 | | 分子名称: | BONE MORPHOGENETIC PROTEIN-7 | | 著者 | Griffith, D.L, Scott, D.L. | | 登録日 | 1995-12-14 | | 公開日 | 1997-07-23 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Proc.Natl.Acad.Sci.USA, 93, 1996
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5NMZ
 | | human Neurturin (97-197) | | 分子名称: | GLYCEROL, Neurturin | | 著者 | Bigalke, J.M, Sandmark, J, Roth, R. | | 登録日 | 2017-04-07 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
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5MR9
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6Y6O
 | | Structure of mature activin A with small molecule 42 | | 分子名称: | (3~{R})-4-ethyl-3-methyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION | | 著者 | McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. | | 登録日 | 2020-02-26 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Chem Sci, 11, 2020
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6Y6N
 | | Structure of mature activin A with small molecule 2 | | 分子名称: | (3~{R})-3,4-dimethyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION | | 著者 | McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. | | 登録日 | 2020-02-26 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Chem Sci, 11, 2020
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6I9J
 | | Human transforming growth factor beta2 in a tetragonal crystal form | | 分子名称: | Transforming growth factor beta-2 proprotein | | 著者 | Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. | | 登録日 | 2018-11-23 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation.
Sci Rep, 9, 2019
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4N1D
 | | Nodal/BMP2 chimera NB250 | | 分子名称: | Nodal/BMP2 chimera protein | | 著者 | Esquivies, L. | | 登録日 | 2013-10-04 | | 公開日 | 2013-12-04 | | 最終更新日 | 2017-07-26 | | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | | 主引用文献 | Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
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7ZJF
 | | R399E, a mutated form of GDF5, for disease modification of osteoarthritis | | 分子名称: | Growth/differentiation factor 5 | | 著者 | Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. | | 登録日 | 2022-04-10 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol, 75, 2023
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1AGQ
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4MID
 | | Crystal Structure of Activin A/BMP2 chimera | | 分子名称: | AB204 Activin A/BMP2 chimera | | 著者 | Esquivies, L. | | 登録日 | 2013-08-30 | | 公開日 | 2014-05-07 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.139 Å) | | 主引用文献 | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29, 2014
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4MPL
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3BMP
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5F3H
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