7XJI
 
 | | Solabegron-activated dog beta3 adrenergic receptor | | 分子名称: | 3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid, Beta-3 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shihoya, W, Nureki, O. | | 登録日 | 2022-04-18 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-06-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of the beta 3 adrenergic receptor bound to solabegron and isoproterenol.
Biochem.Biophys.Res.Commun., 611, 2022
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8GEH
 | | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#18 of 20) | | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | | 登録日 | 2023-03-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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8UO4
 | | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T) | | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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8GEI
 | | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#19 of 20) | | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | | 登録日 | 2023-03-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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7VVO
 | | PTH-bound human PTH1R in complex with Gs (class5) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | | 登録日 | 2021-11-06 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol.Cell, 82, 2022
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5UZ7
 | | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | | 分子名称: | Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M. | | 登録日 | 2017-02-24 | | 公開日 | 2017-05-03 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
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5VAI
 | | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | | 分子名称: | Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. | | 登録日 | 2017-03-27 | | 公開日 | 2017-05-24 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
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7L0P
 | | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, without AHD | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | | 登録日 | 2020-12-12 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
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6GDG
 | | Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Garcia-Nafria, J, Lee, Y. | | 登録日 | 2018-04-23 | | 公開日 | 2018-05-16 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | | 主引用文献 | Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein.
Elife, 7, 2018
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6VU8
 | | Structure of G-alpha-i bound to its chaperone Ric-8A | | 分子名称: | Guanine nucleotide-binding protein G(i) subunit alpha-1, Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | | 著者 | Seven, A.B, Hilger, D. | | 登録日 | 2020-02-14 | | 公開日 | 2020-03-18 | | 最終更新日 | 2020-03-25 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.
Cell Rep, 30, 2020
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7F24
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8GEJ
 | | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#20 of 20) | | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | | 登録日 | 2023-03-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
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7BB6
 | | AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Bous, J, Mouillac, B, Bron, P, Granier, S, Floquet, N, Leyrat, C. | | 登録日 | 2020-12-17 | | 公開日 | 2021-06-02 | | 最終更新日 | 2021-06-30 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex.
Sci Adv, 7, 2021
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7C2E
 | | GLP-1R-Gs complex structure with a small molecule full agonist | | 分子名称: | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. | | 登録日 | 2020-05-07 | | 公開日 | 2020-08-26 | | 最終更新日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the activation of GLP-1R by a small molecule agonist.
Cell Res., 30, 2020
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7L0R
 | | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, without AHD | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | | 登録日 | 2020-12-12 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
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7W0N
 | | Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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6WI9
 | | Human secretin receptor Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Belousoff, M.J, Khoshouei, M. | | 登録日 | 2020-04-09 | | 公開日 | 2020-08-12 | | 最終更新日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
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7L0Q
 | | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, with AHD | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | | 登録日 | 2020-12-12 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-03-31 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
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6QNO
 | | Rhodopsin-Gi protein complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab antibody fragment heavy chain, Fab antibody fragment light chain, ... | | 著者 | Tsai, C.-J, Marino, J, Adaixo, R.J, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N.M.I, Mohammed, I, Matile, H, Dawson, R.J.P, Deupi, X, Stahlberg, H, Schertler, G.F.X. | | 登録日 | 2019-02-11 | | 公開日 | 2019-07-10 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.38 Å) | | 主引用文献 | Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit.
Elife, 8, 2019
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7BB7
 | | AVP-V2R-Galphas-beta1-gamma2-Nb35(T state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Bous, J, Mouillac, B, Bron, P, Granier, S, Floquet, N, Leyrat, C. | | 登録日 | 2020-12-17 | | 公開日 | 2021-06-02 | | 最終更新日 | 2021-06-30 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex.
Sci Adv, 7, 2021
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7YU8
 | | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Akasaka, H, Shihoya, W, Nureki, O. | | 登録日 | 2022-08-16 | | 公開日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
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6CMO
 | | Rhodopsin-Gi complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | | 著者 | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | | 登録日 | 2018-03-05 | | 公開日 | 2018-06-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
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7L0S
 | | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | | 登録日 | 2020-12-12 | | 公開日 | 2021-01-06 | | 最終更新日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
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5JS7
 | | Structural model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings and SAXS | | 分子名称: | Guanine nucleotide-binding protein G(i) subunit alpha-1 | | 著者 | Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F. | | 登録日 | 2016-05-07 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JS8
 | | Structural Model of a Protein alpha subunit in complex with GDP obtained with SAXS and NMR residual couplings | | 分子名称: | Guanine nucleotide-binding protein G(i) subunit alpha-1 | | 著者 | Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F. | | 登録日 | 2016-05-07 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
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