Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 32 件
4DV8
DownloadVisualize
BU of 4dv8 by Molmil
Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
分子名称: (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, Lethal factor, MALONATE ION, ...
著者Margosiak, S.A, Sankaran, B.
登録日2012-02-22
公開日2012-03-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.632 Å)
主引用文献Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg.Med.Chem.Lett., 22, 2012
4PKW
DownloadVisualize
BU of 4pkw by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor GM6001
分子名称: 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
5D1S
DownloadVisualize
BU of 5d1s by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
4PKQ
DownloadVisualize
BU of 4pkq by Molmil
Anthrax toxin lethal factor with bound zinc
分子名称: 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ...
著者Maize, K.M, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKR
DownloadVisualize
BU of 4pkr by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 10
分子名称: CHLORIDE ION, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
5D1T
DownloadVisualize
BU of 5d1t by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
1J7N
DownloadVisualize
BU of 1j7n by Molmil
Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
4PKS
DownloadVisualize
BU of 4pks by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 11
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
1YQY
DownloadVisualize
BU of 1yqy by Molmil
Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
分子名称: (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION
著者Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A.
登録日2005-02-02
公開日2005-05-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4XM6
DownloadVisualize
BU of 4xm6 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4PKU
DownloadVisualize
BU of 4pku by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 15
分子名称: Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKT
DownloadVisualize
BU of 4pkt by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 13
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKV
DownloadVisualize
BU of 4pkv by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 16
分子名称: Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4WF6
DownloadVisualize
BU of 4wf6 by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor MK-31
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2014-09-12
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6521 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
4XM8
DownloadVisualize
BU of 4xm8 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM7
DownloadVisualize
BU of 4xm7 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
1PWU
DownloadVisualize
BU of 1pwu by Molmil
Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
分子名称: 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
DownloadVisualize
BU of 1pww by Molmil
Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
分子名称: LF20, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
DownloadVisualize
BU of 1pwv by Molmil
Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
分子名称: LF20, Lethal factor
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
5D1U
DownloadVisualize
BU of 5d1u by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8503 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
1PWP
DownloadVisualize
BU of 1pwp by Molmil
Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
分子名称: Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
3KWV
DownloadVisualize
BU of 3kwv by Molmil
Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
分子名称: CALCIUM ION, Lethal factor, Protective antigen PA-63
著者Feld, G.K, Kintzer, A.F, Krantz, B.A.
登録日2009-12-01
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers.
Nat.Struct.Mol.Biol., 17, 2010
7KXR
DownloadVisualize
BU of 7kxr by Molmil
Protective antigen pore translocating lethal factor N-terminal domain
分子名称: CALCIUM ION, Lethal factor, Protective antigen
著者Machen, A.J, Freudenthal, B.D.
登録日2020-12-04
公開日2021-07-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism.
Sci Rep, 11, 2021
6ZXJ
DownloadVisualize
BU of 6zxj by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked)
分子名称: Lethal factor, Protective antigen
著者Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
登録日2020-07-29
公開日2020-09-02
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
1PWQ
DownloadVisualize
BU of 1pwq by Molmil
Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
分子名称: Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.52 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004

 

12>

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon