3KWV

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

Summary for 3KWV

Entry DOI	10.2210/pdb3kwv/pdb
Descriptor	Protective antigen PA-63, Lethal factor, CALCIUM ION, ... (4 entities in total)
Functional Keywords	bacillus anthracis, protective antigen, lethal factor, lethal toxin, octamer, protein transport, toxin, protein unfolding, protein translocation, cleavage on pair of basic residues, metal-binding, secreted, virulence, hydrolase, metalloprotease, protease, toxin-protein transport complex, toxin/protein transport
Biological source	Bacillus anthracis More
Cellular location	Secreted, extracellular space: P13423 Secreted: P15917
Total number of polymer chains	6
Total formula weight	307350.72
Authors	Feld, G.K.,Kintzer, A.F.,Krantz, B.A. (deposition date: 2009-12-01, release date: 2010-11-10, Last modification date: 2023-09-06)
Primary citation	Feld, G.K.,Thoren, K.L.,Kintzer, A.F.,Sterling, H.J.,Tang, I.I.,Greenberg, S.G.,Williams, E.R.,Krantz, B.A. Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers. Nat.Struct.Mol.Biol., 17:1383-1390, 2010 Cited by PubMed: 21037566 DOI: 10.1038/nsmb.1923 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.101 Å)

Structure validation