3KWV
Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, E (A, B, D, E) | Protective antigen PA-63 | polymer | 548 | 61484.3 | 4 | UniProt (P13423) Pfam (PF03495) Pfam (PF17475) Pfam (PF17476) Pfam (PF20835) | Bacillus anthracis | PA, PA-83, PA83, Anthrax toxins translocating protein, Protective antigen PA-63, PA63 |
| 2 | C, F (C, F) | Lethal factor | polymer | 263 | 30546.4 | 2 | UniProt (P15917) Pfam (PF07737) | Bacillus anthracis | LF, Anthrax lethal toxin endopeptidase component |
| 3 | G, H, I, J, K... (A, B, D, E) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | O, P, Q, R (A, B, D, E) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 168 - 735 (UniProt: P13423)
| PDB | External Database | Details |
|---|---|---|
| Pro 303 | Val 332 | engineered mutation |
| Gly 304 | His 333 | engineered mutation |
| - | Gly 334 | deletion |
| - | Asn 335 | deletion |
| - | Ala 336 | deletion |
| - | Glu 337 | deletion |
| - | Val 338 | deletion |
| - | His 339 | deletion |
| - | Ala 340 | deletion |
| - | Ser 341 | deletion |
| - | Phe 342 | deletion |
| - | Phe 343 | deletion |
| - | Asp 344 | deletion |
| - | Ile 345 | deletion |
| - | Gly 346 | deletion |
| - | Gly 347 | deletion |
| - | Ser 348 | deletion |
| - | Val 349 | deletion |
| - | Ser 350 | deletion |
| - | Ala 351 | deletion |
| - | Gly 352 | deletion |
| - | Phe 353 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 307030.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 320.6 | |
| All* | Total formula weight | 307350.7 |
