English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3KWV

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0003824	molecular_function	catalytic activity
C	0005576	cellular_component	extracellular region
C	0008237	molecular_function	metallopeptidase activity
C	0046872	molecular_function	metal ion binding
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0003824	molecular_function	catalytic activity
F	0005576	cellular_component	extracellular region
F	0008237	molecular_function	metallopeptidase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 736

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188
A	HOH738

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 737

Chain	Residue
A	SER222
A	LYS225
A	ASP235
A	ASP179
A	ASP181
A	GLU188

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 736

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188
B	HOH738

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 737

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER222
B	LYS225
B	ASP235

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 736

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	GLU188
D	HOH738

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 737

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 736

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	GLU188
E	HOH738

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 737

Chain	Residue
E	ASP179
E	ASP181
E	GLU188
E	SER222
E	LYS225
E	ASP235

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Beta stranded => ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	GLU302-ALA333
A	HIS336-THR345
B	GLU302-ALA333
B	HIS336-THR345
D	GLU302-ALA333
D	HIS336-THR345
E	GLU302-ALA333
E	HIS336-THR345

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0000269\|PubMed:9039918, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP177
E	ASP177
E	ASP181
E	ILE183
A	ASP181
A	ILE183
B	ASP177
B	ASP181
B	ILE183
D	ASP177
D	ASP181
D	ILE183

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0000269\|PubMed:9039918, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP179
B	ASP179
D	ASP179
E	ASP179

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	GLU188
B	GLU188
D	GLU188
E	GLU188

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	SER222
A	LYS225
B	SER222
B	LYS225
D	SER222
D	LYS225
E	SER222
E	LYS225

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP235
B	ASP235
D	ASP235
E	ASP235

site_id	SWS_FT_FI7
Number of Residues	16
Details	SITE: Alpha-clamp => ECO:0000269\|PubMed:21037566

Chain	Residue	Details
A	ARG178
D	LEU187
D	PHE236
D	ILE484
E	ARG178
E	LEU187
E	PHE236
E	ILE484
A	LEU187
A	PHE236
A	ILE484
B	ARG178
B	LEU187
B	PHE236
B	ILE484
D	ARG178

site_id	SWS_FT_FI8
Number of Residues	4
Details	SITE: Cleavage; by chymotrypsin; required for translocation of LF and EF => ECO:0000269\|PubMed:7961869

Chain	Residue	Details
A	ILE334
B	ILE334
D	ILE334
E	ILE334

site_id	SWS_FT_FI9
Number of Residues	4
Details	SITE: Phi-clamp => ECO:0000269\|PubMed:16051798, ECO:0000269\|PubMed:25778700

Chain	Residue	Details
A	GLN447
B	GLN447
D	GLN447
E	GLN447

site_id	SWS_FT_FI10
Number of Residues	4
Details	SITE: Essential for binding to cell receptor => ECO:0000269\|PubMed:12771151

Chain	Residue	Details
A	LYS703
B	LYS703
D	LYS703
E	LYS703

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 641

Chain

Residue

Details

site_id	MCSA2
Number of Residues
Details	M-CSA 641

Chain

Residue

Details

222926

PDB entries from 2024-07-24

PDB statistics

PDBj update info

Contact PDBj

numon