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PDB: 55 件
4WJ8
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Human Pyruvate Kinase M2 Mutant C424A
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ...
著者Mitchell, T, Yuan, M, McNae, I, Morgan, H, Walkinshaw, M.D.
登録日2014-09-29
公開日2015-09-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Human Pyruvate Kinase M2 Mutant C424A
To Be Published
6B6U
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Pyruvate Kinase M2 mutant - S437Y
分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Srivastava, D, Dey, M.
登録日2017-10-03
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 56, 2017
7L21
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Pyruvate Kinase M2 mutant-N70D
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ...
著者Nandi, S, Dey, M.
登録日2020-12-16
公開日2021-12-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2.
Plos One, 18, 2023
4RPP
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crystal structure of PKM2-K422R mutant bound with FBP
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase PKM
著者Wang, P, Sun, C, Zhu, T, Xu, Y.
登録日2014-10-31
公開日2015-02-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.585 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015
4B2D
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BU of 4b2d by Molmil
human PKM2 with L-serine and FBP bound.
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVATE KINASE ISOZYMES M1/M2, ...
著者Chaneton, B, Hillmann, P, Zheng, L, Martin, A.C.L, Maddocks, O.D.K, Chokkathukalam, A, Coyle, J.E, Jankevics, A, Holding, F.P, Vousden, K.H, Frezza, C, O'Reilly, M, Gottlieb, E.
登録日2012-07-13
公開日2012-10-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Nature, 491, 2012
1ZJH
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Structure of human muscle pyruvate kinase (PKM2)
分子名称: Pyruvate kinase, isozymes M1/M2
著者Choe, J, Atanassova, A, Arrowsmith, C, Edwards, A, Sundstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2005-04-28
公開日2005-05-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of human muscle pyruvate kinase (PKM2).
TO BE PUBLISHED
4YJ5
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BU of 4yj5 by Molmil
Crystal structure of PKM2 mutant
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVIC ACID, ...
著者Liu, J.-S, Wu, C.-W, Wang, W.-C.
登録日2015-03-03
公開日2016-03-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
Commun Biol, 2, 2019
3BJF
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Pyruvate kinase M2 is a phosphotyrosine binding protein
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, OXALATE ION, ...
著者Wu, N.
登録日2007-12-03
公開日2008-03-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
3BJT
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Pyruvate kinase M2 is a phosphotyrosine binding protein
分子名称: MAGNESIUM ION, OXALATE ION, Pyruvate kinase isozymes M1/M2
著者Wu, N.
登録日2007-12-04
公開日2008-03-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
6JFB
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Crystal structure of human pyruvate kinase M2 isoform
分子名称: PHOSPHATE ION, Pyruvate kinase PKM Isoform M2, SERINE
著者Chen, T.J, Wang, W.C.
登録日2019-02-08
公開日2020-04-01
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Crystal structure of human pyruvate kinase M2 isoform
To Be Published
3ME3
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BU of 3me3 by Molmil
Activator-Bound Structure of Human Pyruvate Kinase M2
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, Pyruvate kinase isozymes M1/M2, ...
著者Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Inglese, J, Park, H, Structural Genomics Consortium (SGC)
登録日2010-03-31
公開日2010-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
4FXF
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Structure of M2 pyruvate kinase in complex with phenylalanine
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Walkinshaw, M.D, Morgan, H.P.
登録日2012-07-03
公開日2013-03-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FXJ
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Structure of M2 pyruvate kinase in complex with phenylalanine
分子名称: PHENYLALANINE, PHOSPHATE ION, Pyruvate kinase isozymes M1/M2
著者Walkinshaw, M.D, Morgan, H.P.
登録日2012-07-03
公開日2013-03-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
1T5A
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BU of 1t5a by Molmil
Human Pyruvate Kinase M2
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ...
著者Dombrauckas, J.D, Santarsiero, B.D, Mesecar, A.D.
登録日2004-05-03
公開日2005-07-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Biochemistry, 44, 2005
6GG5
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Crystal structure of M2 PYK in complex with Tryptophan.
分子名称: PHOSPHATE ION, POTASSIUM ION, Pyruvate kinase PKM, ...
著者McNae, I.W, Yuan, M, Walkinshaw, M.D.
登録日2018-05-02
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
6GG6
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Crystal structure of M2 PYK in complex with Serine.
分子名称: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
著者McNae, I.W, Yuan, M, Walkinshaw, M.D.
登録日2018-05-02
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
6GG3
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BU of 6gg3 by Molmil
Crystal structure of M2 PYK in complex with Alanine.
分子名称: ALANINE, PHOSPHATE ION, Pyruvate kinase PKM
著者McNae, I.W, Yuan, M, Walkinshaw, M.D.
登録日2018-05-02
公開日2019-09-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.72 Å)
主引用文献An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem.J., 475, 2018
6GG4
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Crystal structure of M2 PYK in complex with Phenyalanine.
分子名称: PHENYLALANINE, PHOSPHATE ION, POTASSIUM ION, ...
著者McNae, I.W, Yuan, M, Walkinshaw, M.D.
登録日2018-05-02
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
4QGC
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BU of 4qgc by Molmil
crystal structure of PKM2-K422R mutant
分子名称: GLYCEROL, POTASSIUM ION, Pyruvate kinase PKM, ...
著者Wang, P, Sun, C, Zhu, T, Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.296 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015
4QG6
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crystal structure of PKM2-Y105E mutant
分子名称: PROLINE, Pyruvate kinase PKM
著者Wang, P, Sun, C, Zhu, T, Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.207 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015
6TTF
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PKM2 in complex with Compound 5
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 5-hydroxynaphthalene-1-sulfonamide, Pyruvate kinase PKM
著者Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
登録日2019-12-27
公開日2020-01-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
6TTI
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PKM2 in complex with Compound 6
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, DIMETHYL SULFOXIDE, Pyruvate kinase PKM, ...
著者Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
登録日2019-12-27
公開日2020-01-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
6TTH
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PKM2 in complex with L-threonine
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase PKM, THREONINE
著者Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
登録日2019-12-27
公開日2020-01-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
6TTQ
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PKM2 in complex with Compound 10
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 1-propan-2-yl-3-pyridin-4-yl-urea, Pyruvate kinase PKM
著者Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
登録日2019-12-30
公開日2020-01-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
4QG8
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crystal structure of PKM2-K305Q mutant
分子名称: GLYCEROL, MAGNESIUM ION, MALONATE ION, ...
著者Wang, P, Sun, C, Zhu, T, Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015

 

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