crystal structure of PKM2-K422R mutant

Summary for 4QGC

Related4QG6 4QG8 4QG9 4RPP
DescriptorPyruvate kinase PKM, POTASSIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywordstetramer, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P14618
Total number of polymer chains4
Total molecular weight234762.02
Wang, P.,Sun, C.,Zhu, T.,Xu, Y. (deposition date: 2014-05-22, release date: 2015-02-25, Last modification date: 2015-03-25)
Primary citation
Wang, P.,Sun, C.,Zhu, T.,Xu, Y.
Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
PubMed: 25645022 (PDB entries with the same primary citation)
DOI: 10.1007/s13238-015-0132-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24040.6%4.3%11.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload