4QGC
crystal structure of PKM2-K422R mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKM | polymer | 535 | 58343.2 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58 |
| 2 | E, J, N, R (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 3 | F, G, H, K, L... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 4 | I, M, Q, U (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 599 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 422 | Lys 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 233372.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1389.3 | |
| All* | Total formula weight | 234762.0 |
