4QGC
crystal structure of PKM2-K422R mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Pyruvate kinase PKM | polymer | 535 | 58343.2 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58 |
2 | A, B, C, D | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | water | water | 18.0 | 599 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 422 | Lys 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 233372.7 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 1389.3 | |
All* | Total formula weight | 234762.0 |