4FXJ

Structure of M2 pyruvate kinase in complex with phenylalanine

Summary for 4FXJ

Entry DOI	10.2210/pdb4fxj/pdb
Related	1BJF 4FXF
Descriptor	Pyruvate kinase isozymes M1/M2, PHOSPHATE ION, PHENYLALANINE, ... (4 entities in total)
Functional Keywords	tim barrel, transferase, phenylalanine binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14618
Total number of polymer chains	4
Total formula weight	241792.42
Authors	Walkinshaw, M.D.,Morgan, H.P. (deposition date: 2012-07-03, release date: 2013-03-27, Last modification date: 2023-09-13)
Primary citation	Morgan, H.P.,O'Reilly, F.J.,Wear, M.A.,O'Neill, J.R.,Fothergill-Gilmore, L.A.,Hupp, T.,Walkinshaw, M.D. M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc.Natl.Acad.Sci.USA, 110:5881-5886, 2013 Cited by PubMed: 23530218 DOI: 10.1073/pnas.1217157110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation