4B2D
human PKM2 with L-serine and FBP bound.
Summary for 4B2D
Entry DOI | 10.2210/pdb4b2d/pdb |
Related | 1T5A |
Descriptor | PYRUVATE KINASE ISOZYMES M1/M2, SERINE, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (6 entities in total) |
Functional Keywords | transferase, tumour, pkm2, glycolysis |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 4 |
Total formula weight | 241156.73 |
Authors | Chaneton, B.,Hillmann, P.,Zheng, L.,Martin, A.C.L.,Maddocks, O.D.K.,Chokkathukalam, A.,Coyle, J.E.,Jankevics, A.,Holding, F.P.,Vousden, K.H.,Frezza, C.,O'Reilly, M.,Gottlieb, E. (deposition date: 2012-07-13, release date: 2012-10-10, Last modification date: 2023-12-20) |
Primary citation | Chaneton, B.,Hillmann, P.,Zheng, L.,Martin, A.C.L.,Maddocks, O.D.K.,Chokkathukalam, A.,Coyle, J.E.,Jankevics, A.,Holding, F.P.,Vousden, K.H.,Frezza, C.,O'Reilly, M.,Gottlieb, E. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature, 491:458-462, 2012 Cited by PubMed: 23064226DOI: 10.1038/nature11540 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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