4B2D

human PKM2 with L-serine and FBP bound.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	PYRUVATE KINASE ISOZYMES M1/M2	polymer	548	59831.8	3	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	HOMO SAPIENS (HUMAN)	PYRUVATE KINASE M2, CYTOSOLIC THYROID HORMONE-BINDING PROTEIN CTHBP, OPA-INTERACTING PROTEIN 3, OIP-3, PYRUVATE KINASE 2/3, PYRUVATE KINASE MUSCLE ISOZYME, THYROID HORMONE-BINDING PROTEIN 1, THBP1, TUMOR M2-PK, P58
2	D (D)	PYRUVATE KINASE ISOZYMES M1/M2	polymer	548	59831.8	1	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	HOMO SAPIENS (HUMAN)	PYRUVATE KINASE M2, CYTOSOLIC THYROID HORMONE-BINDING PROTEIN CTHBP, OPA-INTERACTING PROTEIN 3, OIP-3, PYRUVATE KINASE 2/3, PYRUVATE KINASE MUSCLE ISOZYME, THYROID HORMONE-BINDING PROTEIN 1, THBP1, TUMOR M2-PK, P58
3	E, H, J, M (A, B, C, D)	SERINE	non-polymer		105.1	4	Chemie (SER)
4	F, I, K, N (A, B, C, D)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	4	Chemie (FBP)
5	G, L (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	O, P, Q, R (A, B, C, D)	water	water		18.0	1243	Chemie (HOH)

Sequence modifications

A, B, C: 2 - 531 (UniProt: P14618)

PDB	External Database	Details
Met -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Leu -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Arg 0	-	expression tag
Gly 1	-	expression tag

D: 2 - 531 (UniProt: P14618)

PDB	External Database	Details
Met -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Leu -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Arg 0	-	expression tag
Gly 1	-	expression tag
Leu 142	Ile 142	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	239327.3
Non-Polymers*	Number of molecules	10
	Total formula weight	1829.4
All*	Total formula weight	241156.7

*Water molecules are not included.