4B2D
human PKM2 with L-serine and FBP bound.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | PYRUVATE KINASE ISOZYMES M1/M2 | polymer | 548 | 59831.8 | 3 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | HOMO SAPIENS (HUMAN) | PYRUVATE KINASE M2, CYTOSOLIC THYROID HORMONE-BINDING PROTEIN CTHBP, OPA-INTERACTING PROTEIN 3, OIP-3, PYRUVATE KINASE 2/3, PYRUVATE KINASE MUSCLE ISOZYME, THYROID HORMONE-BINDING PROTEIN 1, THBP1, TUMOR M2-PK, P58 |
| 2 | D (D) | PYRUVATE KINASE ISOZYMES M1/M2 | polymer | 548 | 59831.8 | 1 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | HOMO SAPIENS (HUMAN) | PYRUVATE KINASE M2, CYTOSOLIC THYROID HORMONE-BINDING PROTEIN CTHBP, OPA-INTERACTING PROTEIN 3, OIP-3, PYRUVATE KINASE 2/3, PYRUVATE KINASE MUSCLE ISOZYME, THYROID HORMONE-BINDING PROTEIN 1, THBP1, TUMOR M2-PK, P58 |
| 3 | E, H, J, M (A, B, C, D) | SERINE | non-polymer | 105.1 | 4 | Chemie (SER) PubChem (617) PubChem (5951) PubChem (71077) | |||
| 4 | F, I, K, N (A, B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) PubChem (718) PubChem (10267) PubChem (172313) PubChem (440117) PubChem (5702629) PubChem (12800340) PubChem (16219368) PubChem (24802138) PubChem (46937007) PubChem (445557) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (89534552) PubChem (92209485) PubChem (92209486) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 5 | G, L (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 1243 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 531 (UniProt: P14618)
D: 2 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | expression tag |
| Gly -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Val -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | expression tag |
| Gly -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Val -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Leu 142 | Ile 142 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 239327.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1829.4 | |
| All* | Total formula weight | 241156.7 |
