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PDB: 230 件
3U0T
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Fab-antibody complex
分子名称: Amyloid beta A4 protein, ponezumab HC Fab, ponezumab LC Fab
著者LaPorte, S.L, Pons, J.P.
登録日2011-09-29
公開日2012-01-11
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of C-terminal beta-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease
J.Mol.Biol., 421, 2012
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
分子名称: Type IIIb beta-amyloid 40 Filament
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEL
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BU of 8sel by Molmil
Type IIIb beta-amyloid 40 Filaments from Down Syndrome
分子名称: Amyloid-beta protein 40
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
6SZF
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Solution structure of the amyloid beta-peptide (1-42)
分子名称: Amyloid-beta precursor protein
著者Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M.
登録日2019-10-02
公開日2020-10-14
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study.
Pharmaceuticals, 14, 2021
6TI7
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BU of 6ti7 by Molmil
Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils
分子名称: Amyloid-beta precursor protein
著者Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C.
登録日2019-11-21
公開日2020-07-22
最終更新日2024-06-19
実験手法SOLID-STATE NMR
主引用文献Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
3UMH
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X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium
分子名称: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION
著者Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
登録日2011-11-13
公開日2012-01-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
3SV1
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Crystal structure of APP peptide bound rat Mint2 PARM
分子名称: Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein
著者Shen, Y, Long, J, Yan, X, Xie, X.
登録日2011-07-12
公開日2012-07-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
6TI5
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A New Structural Model of Abeta(1-40) Fibrils
分子名称: Amyloid-beta precursor protein
著者Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A.
登録日2019-11-21
公開日2020-07-22
最終更新日2024-06-19
実験手法SOLID-STATE NMR
主引用文献Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
6TI6
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BU of 6ti6 by Molmil
Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils
分子名称: Amyloid-beta precursor protein
著者Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C.
登録日2019-11-21
公開日2020-07-22
最終更新日2024-06-19
実験手法SOLID-STATE NMR
主引用文献Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
1Z0Q
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Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)
分子名称: Alzheimer's disease amyloid
著者Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D.
登録日2005-03-02
公開日2006-05-23
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding
Chembiochem, 7, 2006
3UMK
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X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper
分子名称: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ...
著者Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
登録日2011-11-13
公開日2012-01-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
1ZE9
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Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation
分子名称: 16-mer from Alzheimer's disease amyloid Protein, ZINC ION
著者Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S.
登録日2005-04-18
公開日2005-05-03
最終更新日2013-10-09
実験手法SOLUTION NMR
主引用文献Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
J.Biol.Chem., 281, 2006
1ZJD
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Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II
分子名称: Catalytic Domain of Coagulation Factor XI, Kunitz Protease Inhibitory Domain of Protease Nexin II
著者Jin, L, Navaneetham, D, Pandey, P, Strickler, J.E, Babine, R.E, Walsh, P.N, Abdel-Meguid, S.S.
登録日2005-04-28
公開日2005-08-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2
J.Biol.Chem., 280, 2005
3UMI
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BU of 3umi by Molmil
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc
分子名称: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ...
著者Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
登録日2011-11-13
公開日2012-01-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
1ZE7
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BU of 1ze7 by Molmil
Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5
分子名称: 16-mer from Alzheimer's disease amyloid Protein
著者Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S.
登録日2005-04-18
公開日2005-05-03
最終更新日2013-10-09
実験手法SOLUTION NMR
主引用文献Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
J.Biol.Chem., 281, 2006
3KTM
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BU of 3ktm by Molmil
Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)
分子名称: (3R)-butane-1,3-diol, ACETATE ION, Amyloid beta A4 protein, ...
著者Dahms, S.O, Hoefgen, S, Roeser, D, Schlott, B, Guhrs, K.H, Than, M.E.
登録日2009-11-25
公開日2010-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
3L81
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Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
分子名称: AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL
著者Mardones, G.A, Rojas, A.L, Burgos, P.V, Dasilva, L.L.P, Prabhu, Y, Bonifacino, J.S, Hurley, J.H.
登録日2009-12-29
公開日2010-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Dev.Cell, 18, 2010
3MXC
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BU of 3mxc by Molmil
Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.
分子名称: AICD peptide, Growth factor receptor-bound protein 2
著者Sen, U, Das, S.
登録日2010-05-07
公開日2011-05-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain.
J.Mol.Biol., 414, 2011
3MXY
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BU of 3mxy by Molmil
Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.
分子名称: AICD peptide E683V variant, Growth factor receptor-bound protein 2
著者Sen, U, Das, S.
登録日2010-05-08
公開日2011-05-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain.
J.Mol.Biol., 414, 2011
3NYL
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BU of 3nyl by Molmil
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
分子名称: Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b
著者Ha, Y, Hu, J, Lee, S, Liu, X, Wang, Y.
登録日2010-07-15
公開日2011-07-13
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Mol.Cell, 15, 2004
3L33
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Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)
分子名称: Amyloid beta A4 protein, CALCIUM ION, FORMIC ACID, ...
著者Salameh, M.A, Soares, A.S, Radisky, E.S.
登録日2009-12-16
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
3OVJ
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BU of 3ovj by Molmil
Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G
分子名称: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, KLVFFA hexapeptide segment from Amyloid beta
著者Landau, M, Eisenberg, D.
登録日2010-09-16
公開日2011-07-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Towards a pharmacophore for amyloid.
Plos Biol., 9, 2011
3PZZ
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Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
分子名称: Amyloid beta A4 protein
著者Soriaga, A.B, Laganowsky, A.L, Sawaya, M.R, Eisenberg, D.
登録日2010-12-14
公開日2011-10-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OW9
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Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II
分子名称: KLVFFA hexapeptide segment from Amyloid beta
著者Landau, M, Eisenberg, D.
登録日2010-09-17
公開日2011-08-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular basis for amyloid-{beta} polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q2X
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Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta
分子名称: Amyloid beta A4 protein
著者Soriaga, A.B, Sawaya, M.R, Eisenberg, D.
登録日2010-12-20
公開日2011-10-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011

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