3U0T

Fab-antibody complex

Summary for 3U0T

• Entry DOI: 10.2210/pdb3u0t/pdb
• Descriptor: ponezumab LC Fab, ponezumab HC Fab, Amyloid beta A4 protein, ... (4 entities in total)
• Functional Keywords: antibody fab, immunotherapeutic, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 6
• Total formula weight: 97303.07

Authors

LaPorte, S.L.,Pons, J.P. (deposition date: 2011-09-29, release date: 2012-01-11, Last modification date: 2013-07-03)

• Primary citation: La Porte, S.L.,Bollini, S.S.,Lanz, T.A.,Abdiche, Y.N.,Rusnak, A.S.,Ho, W.H.,Kobayashi, D.,Harrabi, O.,Pappas, D.,Mina, E.W.,Milici, A.J.,Kawabe, T.T.,Bales, K.,Lin, J.C.,Pons, J.; Structural Basis of C-terminal beta-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease; J.Mol.Biol., 421:525-536, 2012; PubMed: 22197375; DOI: 10.1016/j.jmb.2011.11.047

Experimental method

X-RAY DIFFRACTION (2.5 Å)