1ZJD

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II

Summary for 1ZJD

Entry DOI	10.2210/pdb1zjd/pdb
Related	1ZHM 1ZHP 1ZHR
Descriptor	Catalytic Domain of Coagulation Factor XI, Kunitz Protease Inhibitory Domain of Protease Nexin II (3 entities in total)
Functional Keywords	coagulation factor xi; kunitz protease inhibitory domain; nexin ii, hydrolase, blood clotting
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P03951 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	2
Total formula weight	32988.32
Authors	Jin, L.,Navaneetham, D.,Pandey, P.,Strickler, J.E.,Babine, R.E.,Walsh, P.N.,Abdel-Meguid, S.S. (deposition date: 2005-04-28, release date: 2005-08-09, Last modification date: 2023-08-23)
Primary citation	Navaneetham, D.,Jin, L.,Pandey, P.,Strickler, J.E.,Babine, R.E.,Abdel-Meguid, S.S.,Walsh, P.N. Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2 J.Biol.Chem., 280:36165-36175, 2005 Cited by PubMed: 16085935 DOI: 10.1074/jbc.M504990200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation