1ZJD
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Catalytic Domain of Coagulation Factor XI | polymer | 237 | 26711.3 | 1 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (human) | Plasma thromboplastin antecedent; PTA; FXI |
| 2 | B (B) | Kunitz Protease Inhibitory Domain of Protease Nexin II | polymer | 57 | 6277.0 | 1 | UniProt (P05067) Pfam (PF00014) | Homo sapiens (human) | Amyloid beta A4 protein, isoform b; APP; ABPP; Alzheimer's disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI |
| 3 | C, D (A, B) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ala 75 | Ser 452 | engineered mutation |
| Ala 115 | Thr 493 | engineered mutation |
| Ser 123 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32988.3 | |
| All* | Total formula weight | 32988.3 |
