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PDB: 584 件

8CDY
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N-terminal domain of human apolipoprotein E
分子名称: Maltodextrin-binding protein,Apolipoprotein E
著者Marek, M, Nemergut, M.
登録日2023-02-01
公開日2023-07-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
5M15
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Synthetic nanobody in complex with MBP
分子名称: Maltose-binding periplasmic protein, Synthetic nanobody L2_D09, (a-MBP#3)
著者Zimmermann, I, Egloff, P, Seeger, M.A.
登録日2016-10-07
公開日2017-11-15
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Synthetic single domain antibodies for the conformational trapping of membrane proteins.
Elife, 7, 2018
3OSQ
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BU of 3osq by Molmil
Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 175
分子名称: Maltose-binding periplasmic protein,Green fluorescent protein, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Echevarria, I.M, Marvin, J.S, Looger, L.L, Schreiter, E.R.
登録日2010-09-09
公開日2011-10-26
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A genetically encoded, high-signal-to-noise maltose sensor.
Proteins, 79, 2011
1Y4C
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Designed Helical Protein fusion MBP
分子名称: Maltose binding protein fused with designed helical protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者LaPorte, S.L, Forsyth, C.M, Cunningham, B.C, Miercke, L.J, Akhavan, D, Stroud, R.M.
登録日2004-11-30
公開日2005-02-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献De novo design of an IL-4 antagonist and its structure at 1.9 A.
Proc.Natl.Acad.Sci.Usa, 102, 2005
3Q25
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Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)
分子名称: GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ...
著者Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
登録日2010-12-19
公開日2011-06-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
5B3Y
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Crystal structure of hPin1 WW domain (5-23) fused with maltose-binding protein
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1,Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Hanazono, Y, Takeda, K, Miki, K.
登録日2016-03-17
公開日2016-10-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein
Sci Rep, 6, 2016
4GLI
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BU of 4gli by Molmil
Crystal Structure of Human SMN YG-Dimer
分子名称: Maltose-binding periplasmic protein, Survival motor neuron protein chimera
著者Martin, R.S, Perry, K, Van Duyne, G.D.
登録日2012-08-14
公開日2012-10-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献The survival motor neuron protein forms soluble glycine zipper oligomers.
Structure, 20, 2012
8EL0
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Structure of MBP-Mcl-1 in complex with a macrocyclic compound
分子名称: (7R,20P)-18-chloro-1-(4-fluorophenyl)-10-{[(2M)-2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-7,8,15,16-tetrahydro-14H-17,20-etheno-9,13-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Judge, R.A, Judd, A.S, Souers, A.J.
登録日2022-09-22
公開日2023-10-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.917 Å)
主引用文献Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Commun Med (Lond), 3, 2023
3MP8
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Crystal structure of Sgf29 tudor domain
分子名称: 4-(HYDROXYMETHYL)BENZAMIDINE, ACETIC ACID, GLYCEROL, ...
著者Li, J, Wu, M, Ruan, J, Zang, J.
登録日2010-04-26
公開日2011-05-04
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
Embo J., 30, 2011
8F23
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The crystal structure of a rationally designed zinc sensor based on maltose binding protein - Apo conformation
分子名称: Zinc Sensor protein
著者Zhao, Z, Zhou, M, Zemerov, S.d, Marmorstein, R, Dmochowski, I.J.
登録日2022-11-06
公開日2023-03-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Rational design of a genetically encoded NMR zinc sensor.
Chem Sci, 14, 2023
6UDI
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BU of 6udi by Molmil
X-ray co-crystal structure of compound 20 with Mcl-1
分子名称: (4S,7aR,9aR,10S,11E,18R)-6'-chloro-N-(dimethylsulfamoyl)-18-hydroxy-10-methoxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Huang, X, Whittington, D.
登録日2019-09-19
公開日2019-12-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
J.Med.Chem., 62, 2019
8G3U
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MBP-Mcl1 in complex with ligand 21
分子名称: (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, 1,2-ETHANEDIOL, Maltodextrin-binding protein, ...
著者Miller, B.R, Shaffer, P.
登録日2023-02-08
公開日2023-05-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
7VN3
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BU of 7vn3 by Molmil
Crystal structure of MBP-fused BIL1/BZR1 (21-90) in complex with double-stranded DNA contaning CACACGTGTG
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*CP*AP*CP*GP*TP*GP*TP*GP*AP*AP*A)-3'), Maltodextrin-binding protein,Protein BRASSINAZOLE-RESISTANT 1, ...
著者Nosaki, S, Tanokura, M, Miyakawa, T.
登録日2021-10-10
公開日2022-12-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout.
Nat.Plants, 8, 2022
5C7R
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BU of 5c7r by Molmil
Revealing surface waters on an antifreeze protein by fusion protein crystallography
分子名称: Fusion protein of Maltose-binding periplasmic protein and Type-3 ice-structuring protein HPLC 12, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Sun, T, Gauthier, S, Campbell, R.L, Davies, P.L.
登録日2015-06-24
公開日2015-09-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Revealing Surface Waters on an Antifreeze Protein by Fusion Protein Crystallography Combined with Molecular Dynamic Simulations.
J.Phys.Chem.B, 119, 2015
3H3G
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BU of 3h3g by Molmil
Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in complex with parathyroid hormone-related protein (PTHrP)
分子名称: Fusion protein of Maltose-binding periplasmic domain and human parathyroid hormone receptor extracellular domain, Parathyroid hormone-related protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Pioszak, A.A, Xu, H.E.
登録日2009-04-16
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.
J.Biol.Chem., 284, 2009
3KJ1
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Mcl-1 in complex with Bim BH3 mutant I2dA
分子名称: ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ...
著者Fire, E, Grant, R.A, Keating, A.E.
登録日2009-11-02
公開日2010-02-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.945 Å)
主引用文献Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
7MQ7
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Tetragonal Maltose Binding Protein
分子名称: CHLORIDE ION, Maltodextrin-binding protein, SULFATE ION, ...
著者Thaker, A, Sirajudeen, L, Simmons, C.R, Nannenga, B.L.
登録日2021-05-05
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis.
Biotechnol.Bioeng., 118, 2021
4KYC
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Structure of the C-terminal domain of the Menangle virus phosphoprotein, fused to MBP.
分子名称: 1,2-ETHANEDIOL, BORIC ACID, Maltose-binding periplasmic protein, ...
著者Yegambaram, K, Bulloch, E.M.M, Kingston, R.L.
登録日2013-05-28
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Protein domain definition should allow for conditional disorder.
Protein Sci., 22, 2013
6XRX
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Crystal structure of the mosquito protein AZ1 as an MBP fusion
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, ...
著者Pedersen, L.C, Mueller, G.A, Foo, A.C.Y.
登録日2020-07-14
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.
Proc.Natl.Acad.Sci.USA, 118, 2021
4WVJ
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Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with an inhibitor peptide (pep3).
分子名称: Maltose-binding periplasmic protein,Signal peptidase IB, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, inhibitor peptide (PEP3)
著者Young, P.G, Ting, Y.T, Baker, E.N.
登録日2014-11-05
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization.
IUCrJ, 3, 2016
6MBD
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Human Mcl-1 in complex with the designed peptide dM1
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, dM1
著者Jenson, J.M, Keating, A.E.
登録日2018-08-29
公開日2019-03-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1.
Structure, 27, 2019
6VBX
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Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide
著者Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z.
登録日2019-12-19
公開日2020-12-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
3SEX
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BU of 3sex by Molmil
Ni-mediated Dimer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II)
分子名称: IODIDE ION, Maltose-binding periplasmic protein, NICKEL (II) ION, ...
著者Zhao, M, Soriaga, A.B, Laganowsky, A, Sawaya, M.R, Cascio, D, Yeates, T.O.
登録日2011-06-11
公開日2011-09-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献An approach to crystallizing proteins by metal-mediated synthetic symmetrization.
Protein Sci., 20, 2011
5T0A
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Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate
分子名称: 1,2-ETHANEDIOL, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ...
著者Pedersen, L.C, Moon, A.F, Krahn, J.M, Liu, J.
登録日2016-08-15
公開日2017-02-01
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases.
ACS Chem. Biol., 12, 2017
6B4U
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Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
分子名称: 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Judge, R.A, Souers, A.J.
登録日2017-09-27
公開日2017-10-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J. Med. Chem., 58, 2015

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