3Q25

Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)

Summary for 3Q25

Related3Q26 3Q27 3Q28 3Q29
DescriptorMaltose-binding periplasmic protein/alpha-synuclein chimeric protein, MALTOSE, SULFATE ION, ... (5 entities in total)
Functional Keywordsfusion protein, amyloid, sugar binding protein, protein fibril
Biological sourceEscherichia coli
More
Cellular locationCytoplasm, cytosol  P37840
Total number of polymer chains1
Total molecular weight44551.88
Authors
Zhao, M.,Sawaya, M.R.,Cascio, D.,Eisenberg, D. (deposition date: 2010-12-19, release date: 2011-06-01, Last modification date: 2017-08-02)
Primary citation
Zhao, M.,Cascio, D.,Sawaya, M.R.,Eisenberg, D.
Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20:996-1004, 2011
PubMed: 21462277 (PDB entries with the same primary citation)
DOI: 10.1002/pro.630
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.196401.0%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report