8EL0

Structure of MBP-Mcl-1 in complex with a macrocyclic compound

Summary for 8EL0

• Entry DOI: 10.2210/pdb8el0/pdb
• Related: 8EKX
• Descriptor: Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (7R,20P)-18-chloro-1-(4-fluorophenyl)-10-{[(2M)-2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-7,8,15,16-tetrahydro-14H-17,20-etheno-9,13-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylic acid, ... (4 entities in total)
• Functional Keywords: mbp-mcl-1 fusion protein, apoptosis, inhibitor complex
• Biological source: Escherichia coli; More
• Total number of polymer chains: 1
• Total formula weight: 60379.64

Authors

Judge, R.A.,Judd, A.S.,Souers, A.J. (deposition date: 2022-09-22, release date: 2023-10-04, Last modification date: 2023-11-08)

• Primary citation: Yuda, J.,Will, C.,Phillips, D.C.,Abraham, L.,Alvey, C.,Avigdor, A.,Buck, W.,Besenhofer, L.,Boghaert, E.,Cheng, D.,Cojocari, D.,Doyle, K.,Hansen, T.M.,Huang, K.,Johnson, E.F.,Judd, A.S.,Judge, R.A.,Kalvass, J.C.,Kunzer, A.,Lam, L.T.,Li, R.,Martin, R.L.,Mastracchio, A.,Mitten, M.,Petrich, A.,Wang, J.,Ward, J.E.,Zhang, H.,Wang, X.,Wolff, J.E.,Bell-McGuinn, K.M.,Souers, A.J.; Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.; Commun Med (Lond), 3:154-154, 2023; PubMed: 37880389; DOI: 10.1038/s43856-023-00380-z

Experimental method

X-RAY DIFFRACTION (1.917 Å)