8G3U

MBP-Mcl1 in complex with ligand 21

Summary for 8G3U

Entry DOI	10.2210/pdb8g3u/pdb
Related PRD ID	PRD_900001
Descriptor	Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, physicochemical properties, adme properties, cardiotoxicity, therapeutic window
Biological source	Serratia sp. FS14 More
Total number of polymer chains	1
Total formula weight	58578.72
Authors	Miller, B.R.,Shaffer, P. (deposition date: 2023-02-08, release date: 2023-05-17, Last modification date: 2023-05-24)
Primary citation	Romanov-Michailidis, F.,Hsiao, C.C.,Urner, L.M.,Jerhaoui, S.,Surkyn, M.,Miller, B.,Vos, A.,Dominguez Blanco, M.,Bueters, R.,Vinken, P.,Bekkers, M.,Walker, D.,Pietrak, B.,Eyckmans, W.,Dores-Sousa, J.L.,Joo Koo, S.,Lento, W.,Bauser, M.,Philippar, U.,Rombouts, F.J.R. Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies. J.Med.Chem., 66:6122-6148, 2023 Cited by PubMed: 37114951 DOI: 10.1021/acs.jmedchem.2c01953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation