6VBX
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Summary for 6VBX
Entry DOI | 10.2210/pdb6vbx/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide (3 entities in total) |
Functional Keywords | mcl-1, apoptosis, 138e12 peptide, lys-covalent antagonists |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 19655.35 |
Authors | Pellecchia, M.,Perry, J.J.,Kenjic, N.,Assar, Z. (deposition date: 2019-12-19, release date: 2020-12-30, Last modification date: 2023-10-11) |
Primary citation | Gambini, L.,Udompholkul, P.,Baggio, C.,Muralidharan, A.,Kenjic, N.,Assar, Z.,Perry, J.J.P.,Pellecchia, M. Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1. J.Med.Chem., 64:4903-4912, 2021 Cited by PubMed: 33797903DOI: 10.1021/acs.jmedchem.1c00005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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