6VBX
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 156 | 17850.3 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B (B) | Synthetic peptide | polymer | 13 | 1805.0 | 1 | Pfam (PF08945) UniProt (by SIFTS) (O43521) | synthetic construct | |
| 3 | C, D (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 172 - 323 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 168 | - | expression tag |
| Ser 169 | - | expression tag |
| His 170 | - | expression tag |
| Met 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19655.4 | |
| All* | Total formula weight | 19655.4 |
