5M15
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m15 by Molmil](/molmil-images/mine/5m15) | |
1Y4C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y4c by Molmil](/molmil-images/mine/1y4c) | Designed Helical Protein fusion MBP | 分子名称: | Maltose binding protein fused with designed helical protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | LaPorte, S.L, Forsyth, C.M, Cunningham, B.C, Miercke, L.J, Akhavan, D, Stroud, R.M. | 登録日 | 2004-11-30 | 公開日 | 2005-02-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | De novo design of an IL-4 antagonist and its structure at 1.9 A. Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
1JVY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1jvy by Molmil](/molmil-images/mine/1jvy) | Maltodextrin-binding protein variant D207C/A301GS/P316C with beta-mercaptoethanol mixed disulfides | 分子名称: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltodextrin-binding protein | 著者 | Srinivasan, U, Iyer, G.H, Przybycien, T.A, Samsonoff, W.A, Bell, J.A. | 登録日 | 2001-08-31 | 公開日 | 2001-09-12 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystine: Fibrous Biomolecular Material from Protein Crystals Cross-linked in a Specific Geometry Protein Eng., 15, 2002
|
|
1MDQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mdq by Molmil](/molmil-images/mine/1mdq) | |
5B3Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b3y by Molmil](/molmil-images/mine/5b3y) | |
4GLI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gli by Molmil](/molmil-images/mine/4gli) | |
8EL0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8el0 by Molmil](/molmil-images/mine/8el0) | Structure of MBP-Mcl-1 in complex with a macrocyclic compound | 分子名称: | (7R,20P)-18-chloro-1-(4-fluorophenyl)-10-{[(2M)-2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-7,8,15,16-tetrahydro-14H-17,20-etheno-9,13-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Judge, R.A, Judd, A.S, Souers, A.J. | 登録日 | 2022-09-22 | 公開日 | 2023-10-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.917 Å) | 主引用文献 | Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
|
|
3MP8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mp8 by Molmil](/molmil-images/mine/3mp8) | Crystal structure of Sgf29 tudor domain | 分子名称: | 4-(HYDROXYMETHYL)BENZAMIDINE, ACETIC ACID, GLYCEROL, ... | 著者 | Li, J, Wu, M, Ruan, J, Zang, J. | 登録日 | 2010-04-26 | 公開日 | 2011-05-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J., 30, 2011
|
|
8F23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f23 by Molmil](/molmil-images/mine/8f23) | The crystal structure of a rationally designed zinc sensor based on maltose binding protein - Apo conformation | 分子名称: | Zinc Sensor protein | 著者 | Zhao, Z, Zhou, M, Zemerov, S.d, Marmorstein, R, Dmochowski, I.J. | 登録日 | 2022-11-06 | 公開日 | 2023-03-22 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Rational design of a genetically encoded NMR zinc sensor. Chem Sci, 14, 2023
|
|
8G3U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8g3u by Molmil](/molmil-images/mine/8g3u) | MBP-Mcl1 in complex with ligand 21 | 分子名称: | (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, 1,2-ETHANEDIOL, Maltodextrin-binding protein, ... | 著者 | Miller, B.R, Shaffer, P. | 登録日 | 2023-02-08 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies. J.Med.Chem., 66, 2023
|
|
5C7R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c7r by Molmil](/molmil-images/mine/5c7r) | Revealing surface waters on an antifreeze protein by fusion protein crystallography | 分子名称: | Fusion protein of Maltose-binding periplasmic protein and Type-3 ice-structuring protein HPLC 12, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Sun, T, Gauthier, S, Campbell, R.L, Davies, P.L. | 登録日 | 2015-06-24 | 公開日 | 2015-09-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Revealing Surface Waters on an Antifreeze Protein by Fusion Protein Crystallography Combined with Molecular Dynamic Simulations. J.Phys.Chem.B, 119, 2015
|
|
6UDI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6udi by Molmil](/molmil-images/mine/6udi) | X-ray co-crystal structure of compound 20 with Mcl-1 | 分子名称: | (4S,7aR,9aR,10S,11E,18R)-6'-chloro-N-(dimethylsulfamoyl)-18-hydroxy-10-methoxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Huang, X, Whittington, D. | 登録日 | 2019-09-19 | 公開日 | 2019-12-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J.Med.Chem., 62, 2019
|
|
7VN3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vn3 by Molmil](/molmil-images/mine/7vn3) | Crystal structure of MBP-fused BIL1/BZR1 (21-90) in complex with double-stranded DNA contaning CACACGTGTG | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*CP*AP*CP*GP*TP*GP*TP*GP*AP*AP*A)-3'), Maltodextrin-binding protein,Protein BRASSINAZOLE-RESISTANT 1, ... | 著者 | Nosaki, S, Tanokura, M, Miyakawa, T. | 登録日 | 2021-10-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout. Nat.Plants, 8, 2022
|
|
3H3G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h3g by Molmil](/molmil-images/mine/3h3g) | |
3KJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kj1 by Molmil](/molmil-images/mine/3kj1) | Mcl-1 in complex with Bim BH3 mutant I2dA | 分子名称: | ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... | 著者 | Fire, E, Grant, R.A, Keating, A.E. | 登録日 | 2009-11-02 | 公開日 | 2010-02-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
|
|
6XRX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xrx by Molmil](/molmil-images/mine/6xrx) | Crystal structure of the mosquito protein AZ1 as an MBP fusion | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, ... | 著者 | Pedersen, L.C, Mueller, G.A, Foo, A.C.Y. | 登録日 | 2020-07-14 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
6MBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mbd by Molmil](/molmil-images/mine/6mbd) | Human Mcl-1 in complex with the designed peptide dM1 | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, dM1 | 著者 | Jenson, J.M, Keating, A.E. | 登録日 | 2018-08-29 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1. Structure, 27, 2019
|
|
6VBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vbx by Molmil](/molmil-images/mine/6vbx) | Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide | 著者 | Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z. | 登録日 | 2019-12-19 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1. J.Med.Chem., 64, 2021
|
|
5BJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5bjz by Molmil](/molmil-images/mine/5bjz) | |
6B4U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b4u by Molmil](/molmil-images/mine/6b4u) | Crystal structure of MCL-1 in complex with a BIM competitive inhibitor | 分子名称: | 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Judge, R.A, Souers, A.J. | 登録日 | 2017-09-27 | 公開日 | 2017-10-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J. Med. Chem., 58, 2015
|
|
3SEX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3sex by Molmil](/molmil-images/mine/3sex) | Ni-mediated Dimer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II) | 分子名称: | IODIDE ION, Maltose-binding periplasmic protein, NICKEL (II) ION, ... | 著者 | Zhao, M, Soriaga, A.B, Laganowsky, A, Sawaya, M.R, Cascio, D, Yeates, T.O. | 登録日 | 2011-06-11 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Sci., 20, 2011
|
|
5T0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5t0a by Molmil](/molmil-images/mine/5t0a) | Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate | 分子名称: | 1,2-ETHANEDIOL, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... | 著者 | Pedersen, L.C, Moon, A.F, Krahn, J.M, Liu, J. | 登録日 | 2016-08-15 | 公開日 | 2017-02-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS Chem. Biol., 12, 2017
|
|
3C4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3c4m by Molmil](/molmil-images/mine/3c4m) | |
2XZ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2xz3 by Molmil](/molmil-images/mine/2xz3) | BLV TM hairpin | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MALTOSE ABC TRANSPORTER PERIPLASMIC PROTEIN, ... | 著者 | Schuettelkopf, A.W, Lamb, D, Brighty, D.W, van Aalten, D.M.F. | 登録日 | 2010-11-22 | 公開日 | 2011-03-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Charge-Surrounded Pockets and Electrostatic Interactions with Small Ions Modulate the Activity of Retroviral Fusion Proteins. Plos Pathog., 7, 2011
|
|
7VN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vn5 by Molmil](/molmil-images/mine/7vn5) | Crystal structure of MBP-fused BIL1/BZR1 (21-90) in complex with double-stranded DNA contaning TTCACGTGAA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*TP*TP*CP*AP*CP*GP*TP*GP*AP*AP*AP*AP*A)-3'), Maltodextrin-binding protein,Protein BRASSINAZOLE-RESISTANT 1, ... | 著者 | Nosaki, S, Tanokura, M, Miyakawa, T. | 登録日 | 2021-10-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout. Nat.Plants, 8, 2022
|
|