4CXL
 
 | | Human insulin analogue (D-ProB8)-insulin | | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | | 登録日 | 2014-04-07 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
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4P65
 | | Crystal structure of an cyclohexylalanine substituted insulin analog. | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Pandyarajan, V, Wan, Z, Weiss, M.A. | | 登録日 | 2014-03-21 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
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5EN9
 | | High resolution x-ray crystal structure of isotope-labeled ester-insulin | | 分子名称: | Insulin chain A, Insulin chain B | | 著者 | Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H. | | 登録日 | 2015-11-09 | | 公開日 | 2016-01-13 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
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2C8R
 | | insuline(60sec) and UV laser excited fluorescence | | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D. | | 登録日 | 2005-12-06 | | 公開日 | 2006-03-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops.
Acta Crystallogr.,Sect.D, 62, 2006
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6S4I
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2OMG
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4EYN
 | | Human Insulin | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | | 登録日 | 2012-05-01 | | 公開日 | 2013-05-01 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
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5BQQ
 | | Human insulin with intra-chain chemical crosslink between modified B27 and B30 | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | 登録日 | 2015-05-29 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
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4EXX
 | | Human Insulin | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | | 登録日 | 2012-05-01 | | 公開日 | 2013-05-01 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
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5T7R
 | | A6-A11 trans-dicarba human insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. | | 登録日 | 2016-09-05 | | 公開日 | 2017-12-06 | | 最終更新日 | 2019-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.
Sci Rep, 7, 2017
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2WRU
 | | Semi-synthetic highly active analogue of human insulin NMeAlaB26-DTI- NH2 | | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | 登録日 | 2009-09-02 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6O17
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4UNE
 | | Human insulin B26Phe mutant crystal structure | | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION | | 著者 | Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. | | 登録日 | 2014-05-28 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
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4EYP
 | | Human Insulin | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | | 登録日 | 2012-05-01 | | 公開日 | 2013-05-01 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.591 Å) | | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
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4F1B
 | | Human Insulin | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | | 登録日 | 2012-05-06 | | 公開日 | 2013-05-08 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.591 Å) | | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
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1ZEG
 | | STRUCTURE OF B28 ASP INSULIN IN COMPLEX WITH PHENOL | | 分子名称: | CHLORIDE ION, INSULIN, PHENOL, ... | | 著者 | Whittingham, J.L, Edwards, E.J, Antson, A.A, Clarkson, J.M, Dodson, G.G. | | 登録日 | 1998-05-01 | | 公開日 | 1998-07-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.
Biochemistry, 37, 1998
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3ZU1
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2WS1
 | | Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form | | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | 登録日 | 2009-09-03 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1UZ9
 | | Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins. | | 分子名称: | (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, CHLORIDE ION, INSULIN, ... | | 著者 | Whittingham, J.L, Jonassen, I, Havelund, S, Roberts, S.M, Dodson, E.J, Verma, C.S, Wilkinson, A.J, Dodson, G.G. | | 登録日 | 2004-03-08 | | 公開日 | 2005-03-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins
Biochemistry, 43, 2004
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3E7Y
 | | Structure of human insulin | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Timofeev, V.I, Baidus, A.N, Kislitsyn, Y.A, Kuranova, I.P. | | 登録日 | 2008-08-19 | | 公開日 | 2009-02-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of human insulin
to be published
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3I3Z
 | | Human insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Cuprov-Netochin, R.N, Samigina, V.R, Kuranova, I.P. | | 登録日 | 2009-07-01 | | 公開日 | 2010-01-05 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66, 2010
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4IUZ
 | | High resolution crystal structure of racemic ester insulin | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... | | 著者 | Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. | | 登録日 | 2013-01-22 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
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1TRZ
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6TYH
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6NWV
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