4CXL

Human insulin analogue (D-ProB8)-insulin

Summary for 4CXL

Related4CXN
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, CHLORIDE ION, ... (4 entities in total)
Functional Keywordshormone, diabetes
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5893.17
Authors
Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Jiracek, J.,Moody, N.R.,Turkenburg, J.P.,Brzozowski, A.M.,Zakova, L. (deposition date: 2014-04-07, release date: 2014-05-28, Last modification date: 2014-06-18)
Primary citation
Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Moody, N.R.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.
An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53:3392-, 2014
PubMed: 24819248 (PDB entries with the same primary citation)
DOI: 10.1021/BI500073Z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210604.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution