4CXN

Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I

Summary for 4CXN

Related4CXL
DescriptorINSULIN A CHAIN, INSULIN B CHAIN (3 entities in total)
Functional Keywordshormone, diabetes
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5845.7
Authors
Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Jiracek, J.,Moody, N.R.,Turkenburg, J.P.,Brzozowski, A.M.,Zakova, L. (deposition date: 2014-04-07, release date: 2014-05-28, Last modification date: 2014-06-18)
Primary citation
Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Moody, N.R.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.
An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53:3392-, 2014
PubMed: 24819248 (PDB entries with the same primary citation)
DOI: 10.1021/BI500073Z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2081000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution