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3MFI	DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*(TTD)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2010-04-02 Release date: 2010-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
3MFH	DNA Polymerase Eta in Complex With Undamaged DNA Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*TP*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2010-04-02 Release date: 2010-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
6M7V	Human DNA polymerase eta extension complex with cdA at the -1 position Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(P*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*GP*AP*GP*T)-3'), ... Authors: Weng, P, Gao, Y, Yang, W. Deposit date: 2018-08-21 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.062 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3WUP	Crystal Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Polymerase Eta Descriptor: CHLORIDE ION, DNA polymerase eta, GLYCEROL, ... Authors: Suzuki, N, Wakatsuki, S, Kawasaki, S. Deposit date: 2014-05-01 Release date: 2015-06-17 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Febs J., 283, 2016
7L69	Crystal structure of human polymerase eta complexed with syn N7-benzylguanine Descriptor: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(7BG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA polymerase eta Authors: Jung, H, Lee, S. Deposit date: 2020-12-23 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystal structure of human polymerase eta complexed with syn N7-benzylguanine To Be Published
2I5O	Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta Descriptor: DNA polymerase eta, ZINC ION Authors: Zhou, P, Bomar, M.G. Deposit date: 2006-08-25 Release date: 2007-03-13 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. Embo Rep., 8, 2007
5F9L	CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Patra, A, Egli, M. Deposit date: 2015-12-09 Release date: 2016-12-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.592 Å) Cite: Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta To Be Published
4RNM	Crystal structure of human polymerase eta inserting dAMPnPP opposite DNA template containing an abasic site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primar: AGCGTCAT, DNA Template: CAT(3DR)ATGACGCT, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.144 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
5F9N	CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dCMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Patra, A, Egli, M. Deposit date: 2015-12-09 Release date: 2016-12-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta To Be Published
4RNO	Crystal structure of human polymerase eta extending an abasic site-dA pair by inserting dCTP opposite template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase eta, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
3SI8	Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2) Descriptor: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, ... Authors: Biertumpfel, C, Zhao, Y, Kondo, Y, Ramon-Maiques, S, Gregory, M, Lee, J.Y, Masutani, C, Lehmann, A.R, Hanaoka, F, Yang, W. Deposit date: 2011-06-17 Release date: 2011-08-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
3JAA	HUMAN DNA POLYMERASE ETA in COMPLEX WITH NORMAL DNA AND INCO NUCLEOTIDE (NRM) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*T*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3, DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Lau, W.C.Y, Li, Y, Zhang, Q, Huen, M.S.Y. Deposit date: 2015-05-19 Release date: 2015-12-23 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (22 Å) Cite: Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA Sci Rep, 5, 2015
6D0M	Polymerase Eta post-insertion binary complex with cytarabine (AraC) Descriptor: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ... Authors: Rechkoblit, O, Aggarwal, A.K. Deposit date: 2018-04-10 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.832 Å) Cite: Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8, 2018
6D0Z	Polymerase Eta cytarabine (AraC) extension ternary complex Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ... Authors: Rechkoblit, O, Aggarwal, A.K. Deposit date: 2018-04-11 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8, 2018
3TQ1	Human DNA Polymerase eta in binary complex with DNA Descriptor: DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta Authors: Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2011-09-08 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.556 Å) Cite: Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis. J.Mol.Biol., 415, 2012
2R8J	Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Cisplatin, ... Authors: Carell, T, Alt, A, Lammens, K. Deposit date: 2007-09-11 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta Science, 318, 2007
5VTP	X-ray diffraction data of DNA Polymerase Eta (RAD30) of Saccharomyces cerevisiae with a single magnesium bound in absence of DNA and incoming dNTP Descriptor: DNA polymerase eta, MAGNESIUM ION Authors: Powers, K.T, Washington, M.T. Deposit date: 2017-05-17 Release date: 2018-01-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The C-terminal region of translesion synthesis DNA polymerase eta is partially unstructured and has high conformational flexibility. Nucleic Acids Res., 46, 2018
4Q8E	Human DNA polymerase eta inserting dCMPNPP opposite a phenanthriplatin adducted G Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3', 5'-D(*CP*AP*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3', ... Authors: Gregory, M.T, Yang, W. Deposit date: 2014-04-26 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.549 Å) Cite: Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
4Q8F	Human DNA polymerase eta extending primer immediately after a phenanthriplatin adducted G Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*C)-3', 5'-D(*CP*AP*TP*CP*GP*TP*CP*AP*CP*AP*CP*T)-3', ... Authors: Gregory, M.T, Yang, W. Deposit date: 2014-04-26 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.797 Å) Cite: Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
6PL8	Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Koag, M.C, Lee, S. Deposit date: 2019-06-30 Release date: 2020-07-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP To Be Published
6UI2	Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Koag, M.C, Lee, S. Deposit date: 2019-09-30 Release date: 2020-01-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta. Molecules, 24, 2019
6UQI	Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Jung, H, Lee, S. Deposit date: 2019-10-19 Release date: 2020-10-28 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) To Be Published
4YQW	Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-13 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.064 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
8SKI	Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across HX Descriptor: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Jung, H. Deposit date: 2023-04-19 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.163 Å) Cite: Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA To Be Published
4YR3	Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite Template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-14 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015

 

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