5DG9

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dGMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION

Summary for 5DG9

Related5DG7 5DG8 5DGA 5DGB
DescriptorDNA polymerase eta, DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
Functional Keywordsdna polymerase, dna enzyme, dna damage, translesion dna synthesis, etheno dna adducts, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total molecular weight55361.65
Authors
Patra, A.,Egli, M. (deposition date: 2015-08-27, release date: 2016-06-08, Last modification date: 2019-01-16)
Primary citation
Patra, A.,Su, Y.,Zhang, Q.,Johnson, K.M.,Guengerich, F.P.,Egli, M.
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291:14134-14145, 2016
PubMed: 27226627 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.732487
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2227 0.2% 1.1% 6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution