6D0Z
Polymerase Eta cytarabine (AraC) extension ternary complex
Summary for 6D0Z
Entry DOI | 10.2210/pdb6d0z/pdb |
Related | 6D0M |
Descriptor | DNA polymerase eta, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*G)-R(P*(CAR))-3'), ... (7 entities in total) |
Functional Keywords | cytarabine, arac, dna damage, translesion, dna synthesis, dna replication, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55449.75 |
Authors | Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2018-04-11, release date: 2018-09-05, Last modification date: 2023-10-04) |
Primary citation | Rechkoblit, O.,Choudhury, J.R.,Buku, A.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8:12702-12702, 2018 Cited by PubMed: 30140014DOI: 10.1038/s41598-018-30796-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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