Crystal structure of human polymerase eta inserting datp opposite an 8-oxog containing dna template

Summary for 4O3O

Related4O3N 4O3P 4O3Q 4O3R 4O3S
DescriptorDNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
Functional Keywordscatalytic domain, dna, dna damage, dna-directed dna polymerase, cytosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, 8-oxog lesion bypass, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9Y253
Total number of polymer chains3
Total molecular weight55353.63
Patra, A.,Egli, M. (deposition date: 2013-12-18, release date: 2014-04-30, Last modification date: 2014-07-02)
Primary citation
Patra, A.,Nagy, L.D.,Zhang, Q.,Su, Y.,Muller, L.,Guengerich, F.P.,Egli, M.
Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289:16867-16882, 2014
PubMed: 24759104 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.551820
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21950.5%1.1%7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16