4O3Q
Crystal structure of human polymerase eta inserting dgtp opposite an 8-oxog containing dna template
Summary for 4O3Q
Entry DOI | 10.2210/pdb4o3q/pdb |
Related | 4O3N 4O3O 4O3P 4O3R 4O3S |
Descriptor | DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total) |
Functional Keywords | catalytic domain, dna, dna damage, dna-directed dna polymerase, cytosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, 8-oxog lesion bypass, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9Y253 |
Total number of polymer chains | 3 |
Total formula weight | 55369.63 |
Authors | |
Primary citation | Patra, A.,Nagy, L.D.,Zhang, Q.,Su, Y.,Muller, L.,Guengerich, F.P.,Egli, M. Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta J.Biol.Chem., 289:16867-16882, 2014 Cited by PubMed: 24759104DOI: 10.1074/jbc.M114.551820 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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