4E17
| Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin | Descriptor: | Catenin alpha-1, Vinculin | Authors: | Choi, H.-J, Pokutta, S, Cadwell, G.W, Bankston, L.A, Liddington, R.C, Weis, W.I. | Deposit date: | 2012-03-05 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Conformational plasticity of alpha-catenin revealed by binding interactions with vinculin To be Published
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6DUW
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4EHP
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6BFI
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3MYI
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5H5M
| Crystal structure of HMP-1 M domain | Descriptor: | Alpha-catenin-like protein hmp-1 | Authors: | Kang, H, Bang, I, Weis, W.I, Choi, H.J. | Deposit date: | 2016-11-08 | Release date: | 2017-03-29 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional characterization of Caenorhabditis elegans alpha-catenin reveals constitutive binding to beta-catenin and F-actin J. Biol. Chem., 292, 2017
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1L7C
| alpha-catenin fragment, residues 385-651 | Descriptor: | Alpha E-catenin | Authors: | Pokutta, S, Drees, F, Takai, Y, Nelson, W.J, Weis, W.I. | Deposit date: | 2002-03-14 | Release date: | 2002-06-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J.Biol.Chem., 277, 2002
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1H6G
| alpha-catenin M-domain | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ALPHA-1 CATENIN, CALCIUM ION, ... | Authors: | Yang, J, Dokurno, P, Tonks, N.K, Barford, D. | Deposit date: | 2001-06-14 | Release date: | 2001-08-07 | Last modified: | 2016-02-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of the M-Fragment of Alpha-Catenin: Implications for Modulation of Cell Adhesion. Embo J., 20, 2001
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1QKR
| Crystal structure of the vinculin tail and a pathway for activation | Descriptor: | SULFATE ION, VINCULIN | Authors: | Bakolitsa, C, De Pereda, J.M, Bagshaw, C.R, Critchley, D.R, Liddington, R.C. | Deposit date: | 1999-08-04 | Release date: | 2000-08-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Vinculin Tail and a Pathway for Activation Cell(Cambridge,Mass.), 99, 1999
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6NR7
| Rerefinement of chicken vinculin | Descriptor: | (1R,2R,3S,4R,5R,6S)-4-{[(S)-[(2S)-2,3-dihydroxypropoxy](hydroxy)phosphoryl]oxy}-3,5,6-trihydroxycyclohexane-1,2-diyl bis[dihydrogen (phosphate)], PHOSPHATE ION, SULFATE ION, ... | Authors: | Stec, B. | Deposit date: | 2019-01-23 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Refined model of chicken vinculin suggests the mechanism of activation by helical super-bundle unfurling To be published
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6O3E
| mouse aE-catenin 82-883 | Descriptor: | Catenin alpha-1 | Authors: | Pokutta, S, Weis, W.I. | Deposit date: | 2019-02-26 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.001 Å) | Cite: | Binding partner- and force-promoted changes in alpha E-catenin conformation probed by native cysteine labeling. Sci Rep, 9, 2019
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3S90
| Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546) | Descriptor: | Talin-1, Vinculin | Authors: | Yogesha, S.D, Sharff, A, Bricogne, G, Izard, T. | Deposit date: | 2011-05-31 | Release date: | 2011-06-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin. Protein Sci., 20, 2011
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6DUY
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3TJ5
| human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-N; residues 412-434) from Rickettsia rickettsii | Descriptor: | Antigenic heat-stable 120 kDa protein, GLYCEROL, Vinculin | Authors: | Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T. | Deposit date: | 2011-08-23 | Release date: | 2011-09-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. J.Biol.Chem., 286, 2011
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5XA5
| Crystal structure of HMP-1-HMP-2 complex | Descriptor: | Alpha-catenin-like protein hmp-1, Beta-catenin-like protein hmp-2 | Authors: | Shao, X, Kang, H, Weis, W.I, Hardin, J, Choi, H.J. | Deposit date: | 2017-03-11 | Release date: | 2017-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the alpha-catenin· beta-catenin-binding interface. J.Biol.Chem., 292, 2017
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5XFL
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5Y04
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6FQ4
| Structure of Chlamydial virulence factor TarP and vinculin head domain | Descriptor: | TarP-VBS1, Vinculin | Authors: | Whitewood, A.J, Singh, A.K, Brown, D.G, Goult, B.T. | Deposit date: | 2018-02-13 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex. FEBS Lett., 592, 2018
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6FUY
| Crystal structure of human full-length vinculin-T12-A974K (residues 1-1066) | Descriptor: | CALCIUM ION, Vinculin | Authors: | Chorev, D.S, Volberg, T, Livne, A, Eisenstein, M, Martins, B, Kam, Z, Jockusch, B.M, Medalia, O, Sharon, M, Geiger, B. | Deposit date: | 2018-02-28 | Release date: | 2018-03-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Conformational states during vinculin unlocking differentially regulate focal adhesion properties. Sci Rep, 8, 2018
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4K1N
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4ONS
| Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation | Descriptor: | Catenin alpha-2, Catenin beta-1 | Authors: | Pokutta, S, Choi, H.-J, Ahlsen, G, Hansen, S.D, Weis, W.I. | Deposit date: | 2014-01-29 | Release date: | 2014-04-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Thermodynamic Characterization of Cadherin beta-Catenin alpha-Catenin Complex Formation. J.Biol.Chem., 289, 2014
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3ZDL
| Vinculin head (1-258) in complex with a RIAM fragment | Descriptor: | AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN, VINCULIN | Authors: | Zacharchenko, T, Elliott, P.R, Goult, B.T, Bate, N, Critchely, D.R, Barsukov, I.L. | Deposit date: | 2012-11-28 | Release date: | 2013-02-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Riam and Vinculin Binding to Talin are Mutually Exclusive and Regulate Adhesion Assembly and Turnover. J.Biol.Chem., 288, 2013
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4P9T
| Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin | Descriptor: | 1,2-ETHANEDIOL, Catenin alpha-2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Shibahara, T, Hirano, Y, Hakoshima, T. | Deposit date: | 2014-04-04 | Release date: | 2015-04-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin. Febs Lett., 589, 2015
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4K1O
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3TJ6
| human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii | Descriptor: | Antigenic heat-stable 120 kDa protein, Vinculin | Authors: | Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T. | Deposit date: | 2011-08-23 | Release date: | 2011-09-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. J.Biol.Chem., 286, 2011
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