Crystal structure of human full-length vinculin-T12-A974K (residues 1-1066)

Replaces:  6FMM

Summary for 6FUY

DescriptorVinculin, CALCIUM ION (3 entities in total)
Functional Keywordsmechanosensitive self-inhibition adapter, cell adhesion
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Peripheral membrane protein ; Cytoplasmic side  P18206
Total number of polymer chains1
Total molecular weight116699.31
Primary citation
Chorev, D.S.,Volberg, T.,Livne, A.,Eisenstein, M.,Martins, B.,Kam, Z.,Jockusch, B.M.,Medalia, O.,Sharon, M.,Geiger, B.
Conformational states during vinculin unlocking differentially regulate focal adhesion properties.
Sci Rep, 8:2693-2693, 2018
PubMed: 29426917 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-018-21006-8
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.315110.5%1.3%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6fuy
no rotation
Molmil generated image of 6fuy
rotated about x axis by 90°
Molmil generated image of 6fuy
rotated about y axis by 90°
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